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• W2055048380 endingPage "29" @default.
• W2055048380 startingPage "15" @default.
• W2055048380 abstract "Learning a conditioned stimulus (CS)-unconditioned stimulus (US) association is accompanied by a variety of long-lasting changes in physiology and chemistry of the synapse in the dentate gyrus. To determine the time course of synaptic modification during learning, changes in the perforant path-dentate gyrus-evoked field potentials were measured in rats performing a classical conditioning (paired tone and footshock) or pseudoconditioning (unpaired tone and footshock) task. Over the course of 4 days of training, differential changes in the evoked response were observed in the two groups. In the conditioned group, there was an increase in the slope of the excitatory postsynaptic potential (EPSP) which started after five tone-shock paired trials and lasted for more than 40 min, outlasting the training session by 20 min. In contrast, a decrease in the slope of the EPSP which commenced after training and lasted for at least 1 h was observed in the pseudoconditioned group. In both groups there was a prolonged decrease in the amplitude of the population spike. The increase in the EPSP was reduced and the duration tended to shorten over days of training in the conditioned group, whereas in the pseudoconditioned group the decrease in the EPSP tended to increase. Off-line analysis of suppression of lever-pressing for food reward during the presentation of the tone, indicated that the conditioned rats had learned the tone-footshock association. Temperature was measured in the dentate gyrus of rats undergoing an identical procedure. In both groups slight temperature increases were observed, with no difference in amplitude and time-course between the groups. The differential effect of conditioning and pseudoconditioning on the evoked response and changes in temperature eliminate the possibility that effects of stress, arousal and muscular effort are the primary cause of the changes in the EPSP. The results suggest that behavioural events can exert bidirectional control of synaptic strength of entorhinal cortex inputs to the dentate gyrus and that the sign of synaptic modification is at least in part determined by the temporal relationship between these events. The data are discussed in terms of the type of neural activity that may mediate the processing of information in the dentate gyrus." @default.
• W2055048380 created "2016-06-24" @default.
• W2055048380 creator A5006647859 @default.
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• W2055048380 date "1995-09-01" @default.
• W2055048380 modified "2023-10-18" @default.
• W2055048380 title "Potentiation or depression of synaptic efficacy in the dentate gyrus is determined by the relationship between the conditioned and unconditioned stimulus in a classical conditioning paradigm in rats" @default.
• W2055048380 cites W142141443 @default.
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• W2055048380 cites W1539042965 @default.
• W2055048380 cites W1550302433 @default.
• W2055048380 cites W1577989916 @default.
• W2055048380 cites W1733248925 @default.
• W2055048380 cites W1880474948 @default.
• W2055048380 cites W1976266567 @default.
• W2055048380 cites W1979153815 @default.
• W2055048380 cites W1981023600 @default.
• W2055048380 cites W1981293922 @default.
• W2055048380 cites W1982929307 @default.
• W2055048380 cites W1983923341 @default.
• W2055048380 cites W1993725941 @default.
• W2055048380 cites W1996088954 @default.
• W2055048380 cites W2000130476 @default.
• W2055048380 cites W2003406319 @default.
• W2055048380 cites W2004743396 @default.
• W2055048380 cites W2006594450 @default.
• W2055048380 cites W2008085800 @default.
• W2055048380 cites W2009782005 @default.
• W2055048380 cites W2012835383 @default.
• W2055048380 cites W2017283621 @default.
• W2055048380 cites W2018827001 @default.
• W2055048380 cites W2021024875 @default.
• W2055048380 cites W2022036926 @default.
• W2055048380 cites W2022142272 @default.
• W2055048380 cites W2022447157 @default.
• W2055048380 cites W2024986310 @default.
• W2055048380 cites W2025801062 @default.
• W2055048380 cites W2025835757 @default.
• W2055048380 cites W2026859048 @default.
• W2055048380 cites W2032753391 @default.
• W2055048380 cites W2040657121 @default.
• W2055048380 cites W2043116482 @default.
• W2055048380 cites W2043142806 @default.
• W2055048380 cites W2045933298 @default.
• W2055048380 cites W2046388858 @default.
• W2055048380 cites W2049511526 @default.
• W2055048380 cites W2050841371 @default.
• W2055048380 cites W2051150606 @default.
• W2055048380 cites W2054077218 @default.
• W2055048380 cites W2058709617 @default.
• W2055048380 cites W2058938422 @default.
• W2055048380 cites W2066609954 @default.
• W2055048380 cites W2067416002 @default.
• W2055048380 cites W2067488971 @default.
• W2055048380 cites W2072766399 @default.
• W2055048380 cites W2073055671 @default.
• W2055048380 cites W2073965502 @default.
• W2055048380 cites W2075334957 @default.
• W2055048380 cites W2077758457 @default.
• W2055048380 cites W2082093869 @default.
• W2055048380 cites W2086755923 @default.
• W2055048380 cites W2089502569 @default.
• W2055048380 cites W2092250620 @default.
• W2055048380 cites W2092710486 @default.
• W2055048380 cites W2092913056 @default.
• W2055048380 cites W2094214463 @default.
• W2055048380 cites W2094319585 @default.
• W2055048380 cites W2094641619 @default.
• W2055048380 cites W2113113108 @default.
• W2055048380 cites W2119051448 @default.
• W2055048380 cites W2135711081 @default.
• W2055048380 cites W2141949285 @default.
• W2055048380 cites W2146060653 @default.
• W2055048380 cites W2149274294 @default.
• W2055048380 cites W2171952745 @default.
• W2055048380 cites W2258993652 @default.
• W2055048380 cites W2399268850 @default.
• W2055048380 cites W2413410014 @default.
• W2055048380 cites W4214891130 @default.
• W2055048380 cites W4251605594 @default.
• W2055048380 cites W4253341283 @default.
• W2055048380 doi "https://doi.org/10.1016/0166-4328(94)00179-j" @default.
• W2055048380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8519425" @default.
• W2055048380 hasPublicationYear "1995" @default.
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