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• W2055052061 abstract "Purpose of review Expression profiling of genes and proteins using a growing number of high-throughput technologies has facilitated developing a global view of biologic systems in health and disease. These technologies have now taken a center stage in the process of gene discovery and are contributing to advances in our understanding of gene and protein functionality. These tools also provide a robust and efficient way of looking at how multiple genes and proteins interact in functional networks, although we look forward to more progress in this area. Data from DNA microarrays and proteomics can also be used to identify candidate genes as potential diagnostic, prognostic, or therapeutic markers. In fact, it is likely that the first clinical applications of these genomic technologies will be in diagnostics, and we see this happening now, becoming common in the next few years. Recent findings In kidney transplantation, these techniques are accelerating the search for the mechanisms of immune-mediated acute rejection and the kidney injury, fibrosis, and tubular atrophy of chronic allograft nephropathy. Studies in liver transplantation have focused on mechanisms of liver injury from hepatitis and the pathogenesis of hepatocellular carcinoma. In heart and lung transplantation, the focus has been on the progression of coronary artery disease and bronchiolitis obliterans, respectively. Thus, each field of transplantation has taken advantage of these emerging technologies. Summary Rapid improvements in computational methods are helping to deal with the vast amount of sequence and other data these genomic and proteomic tools generate, creating new opportunities to apply genomics and proteomics to clinical medicine." @default.
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• W2055052061 date "2005-09-01" @default.
• W2055052061 modified "2023-09-26" @default.
• W2055052061 title "Genomics and proteomics in transplantation" @default.
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• W2055052061 doi "https://doi.org/10.1097/01.mot.0000171199.91610.48" @default.
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