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- W2055059689 abstract "Escherichia coli is the organism of choice for the expression of a wide variety of recombinant proteins for therapeutic, diagnostic and industrial applications. E. coli generates acetic acid (acetate) as an undesirable by-product that has several negative effects on protein production. Various strategies have been developed to limit acetate accumulation or reduce its negative effects to increase the productivity of recombinant proteins. This article reviews recent strategies for reducing or eliminating acetate, including approaches that optimize the protein production process as well as those that involve modifying the host organism itself. Escherichia coli is the organism of choice for the expression of a wide variety of recombinant proteins for therapeutic, diagnostic and industrial applications. E. coli generates acetic acid (acetate) as an undesirable by-product that has several negative effects on protein production. Various strategies have been developed to limit acetate accumulation or reduce its negative effects to increase the productivity of recombinant proteins. This article reviews recent strategies for reducing or eliminating acetate, including approaches that optimize the protein production process as well as those that involve modifying the host organism itself." @default.
- W2055059689 created "2016-06-24" @default.
- W2055059689 creator A5015313588 @default.
- W2055059689 creator A5085121762 @default.
- W2055059689 date "2006-11-01" @default.
- W2055059689 modified "2023-09-30" @default.
- W2055059689 title "Overcoming acetate in Escherichia coli recombinant protein fermentations" @default.
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- W2055059689 doi "https://doi.org/10.1016/j.tibtech.2006.09.001" @default.
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- W2055059689 hasPublicationYear "2006" @default.
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