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- W2055069892 abstract "Summary. An analogue model of human granulopoiesis incorporating feedback control is presented which is less restricted than previous models. The model simulates kinetic data from human DF32 P and 3H-thymidine labelling experiments, and the data obtained by Morley & Stohlman in mice (1970) following destruction of four-fifths of the marrow. Support for King-Smith & Morley's (1970) suggestion that cyclic neutropenia may be a stem cell defect is forthcoming, but only after the addition of a further negative feedback loop simulating a granulocyte‘chalone’ or a considerable reduction in the time required for precursor cell division. The value of the model in the interpretation and design of kinetic studies, particularly in the non-steady state, is discussed." @default.
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- W2055069892 date "1973-07-01" @default.
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- W2055069892 title "An Analogue Model of Granulopoiesis for the Analysis of Isotopic and Other Data Obtained in the Non-steady State" @default.
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- W2055069892 doi "https://doi.org/10.1111/j.1365-2141.1973.tb01712.x" @default.
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