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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055072950> ?p ?o ?g. }

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• W2055072950 abstract "To find out the effect of miR-544a on the invasion of lung cancer cells and to explore the underlying molecular mechanisms.Micro-ribonucleic acid (miRNA) expression in two different invasive lung cancer cell lines 95C (low invasive ability) and 95D (high invasive ability) was analyzed by miRNA microarray and real-time quantitative polymerase chain reaction (PCR); miR-544a mimic was transfected to 95C, and its invasion ability was detected by transwell migration assay; we predicted the candidate miRNA target genes by TargetScan (Whitehead Institute for Biomedical Research, Cambridge, MA, USA) software and verified the target genes by Western blot.The expression of miR-544a was significantly increased in 95D in miRNA microarray and quantitative PCR tests (P<0.05). After being transfected with miR-544a mimic, the invasion ability of 95C was enhanced (P<0.01). Moreover, transfection with miR-544a inhibitor decreased the invasion ability of 95D (P<0.01). miR-544a possibly combined with CDH1 (E-cadherin) predicted by the TargetScan analysis. 95C with miR-544a mimic reduced the expression of CDH1 and improved the expression of vimentin, while 95D with miR-544a inhibitor improved the expression of CDH1 and reduced the expression of vimentin.miR-544a can promote the invasion of non-small cell lung cancer by downregulation of CDH1 and upregulation of vimentin." @default.
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• W2055072950 date "2014-06-01" @default.
• W2055072950 modified "2023-09-25" @default.
• W2055072950 title "miR-544a promotes the invasion of lung cancer cells by targeting cadherina 1 in vitro" @default.
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• W2055072950 doi "https://doi.org/10.2147/ott.s61695" @default.
• W2055072950 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4051809" @default.
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