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• W2055075230 abstract "Pathogenesis of vascular calcification in chronic kidney disease.BackgroundHyperphosphatemia and hypercalcemia are independent risk factors for higher incidence of cardiovascular events in patients with chronic kidney disease. In addition to increased calcium-phosphate product, hyperphosphatemia accelerates the progression of secondary hyperparathyroidism with the concomitant bone loss, possibly linked to vascular calcium-phosphate precipitation.ResultsThe control of serum phosphate levels reduces vascular calcification not only by decreasing the degree of secondary hyperparathyroidism and calcium-phosphate product, but also by reducing the expression of proteins responsible for active bone mineral deposition in cells of the vasculature. The calcium and aluminum-free phosphate-binders provide a new and effective therapeutic tool in preventing vascular calcifications in chronic kidney disease in animal models and in hemodialysis patients.ConclusionAdditional investigations are necessary to examine the benefits of different phosphate-binders in reducing mortality from cardiovascular disease. Pathogenesis of vascular calcification in chronic kidney disease. Hyperphosphatemia and hypercalcemia are independent risk factors for higher incidence of cardiovascular events in patients with chronic kidney disease. In addition to increased calcium-phosphate product, hyperphosphatemia accelerates the progression of secondary hyperparathyroidism with the concomitant bone loss, possibly linked to vascular calcium-phosphate precipitation. The control of serum phosphate levels reduces vascular calcification not only by decreasing the degree of secondary hyperparathyroidism and calcium-phosphate product, but also by reducing the expression of proteins responsible for active bone mineral deposition in cells of the vasculature. The calcium and aluminum-free phosphate-binders provide a new and effective therapeutic tool in preventing vascular calcifications in chronic kidney disease in animal models and in hemodialysis patients. Additional investigations are necessary to examine the benefits of different phosphate-binders in reducing mortality from cardiovascular disease." @default.
• W2055075230 created "2016-06-24" @default.
• W2055075230 creator A5003294187 @default.
• W2055075230 creator A5008053180 @default.
• W2055075230 creator A5010927626 @default.
• W2055075230 creator A5024121378 @default.
• W2055075230 date "2005-08-01" @default.
• W2055075230 modified "2023-10-18" @default.
• W2055075230 title "Pathogenesis of vascular calcification in chronic kidney disease" @default.
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• W2055075230 doi "https://doi.org/10.1111/j.1523-1755.2005.00421.x" @default.
• W2055075230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16014020" @default.
• W2055075230 hasPublicationYear "2005" @default.
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