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- W2055087658 abstract "The purpose of this study was to determine whether the Laurus nobilis chloroform fraction (LNCF) protects against cerebral ischemia neuronal damage. Human neuroblastoma SH-SY5Y cells and brain slices from rats were subjected to oxygen and glucose deprivation (OGD), followed by reoxgenation with and without LNCF. The viabilities of SH-SY5Y cells and brain slices from the rats were 58.5±4.9% and 79.7±5.9% in the group subjected to OGD, and 80.4±0.4% and 97.2±1.9% at 4 µg/ml of LNCF, respectively. LNCF also significantly inhibited death-associated protein kinase (DAPK) dephosphorylation. Pretreatment with LNCF at 4 mg/kg significantly decreased infarct size by 79% of vehicle control in the middle cerebral artery occlusion (MCAO) in vivo model. LNCF is a neuroprotective drug candidate against cerebral ischemia neuronal damage." @default.
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- W2055087658 date "2010-10-23" @default.
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- W2055087658 title "Amelioration of Oxygen and Glucose Deprivation-Induced Neuronal Death by Chloroform Fraction of Bay Leaves (<i>Laurus nobilis</i>)" @default.
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- W2055087658 doi "https://doi.org/10.1271/bbb.100301" @default.
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