Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055097128> ?p ?o ?g. }
- W2055097128 endingPage "2285" @default.
- W2055097128 startingPage "2281" @default.
- W2055097128 abstract "A microbial screen using a yeast strain with conditional deficiency in the GPA1 gene was carried out to search for inhibitors of protein farnesyltransferase (PFT). A strain of Streptomyces was found to produce active compounds named UCF1-A, UCF1-B, and UCF1-C. Structural determination of these compounds revealed that UCF1-C is identical to the known antibiotic, manumycin, whereas UCF1-A and UCF1-B are structurally related to manumycin. All three UCF1 compounds suppress the lethality of gpa1 disruption, with UCF1-C exhibiting the strongest activity. UCF1 inhibits yeast as well as rat brain PFT. Fifty percent inhibition of yeast PFT activity is observed with 5 microM UCF1-C. Kinetic analyses of the inhibition suggest that UCF1-C acts as a competitive inhibitor of PFT with respect to farnesyl pyrophosphate, exhibiting a Ki of 1.2 microM, whereas the same compound appears to act as a noncompetitive inhibitor of PFT with respect to the farnesyl acceptor, the Ras protein. UCF1-C shows significant activity to inhibit the growth of Ki-ras-transformed fibrosarcoma, raising the possibility of its use as an antitumor drug." @default.
- W2055097128 created "2016-06-24" @default.
- W2055097128 creator A5012279033 @default.
- W2055097128 creator A5021949734 @default.
- W2055097128 creator A5024393250 @default.
- W2055097128 creator A5025349103 @default.
- W2055097128 creator A5026791776 @default.
- W2055097128 creator A5054135230 @default.
- W2055097128 creator A5058150457 @default.
- W2055097128 creator A5063363278 @default.
- W2055097128 creator A5066216857 @default.
- W2055097128 date "1993-03-15" @default.
- W2055097128 modified "2023-10-16" @default.
- W2055097128 title "Identification of Ras farnesyltransferase inhibitors by microbial screening." @default.
- W2055097128 cites W1503864937 @default.
- W2055097128 cites W1505669099 @default.
- W2055097128 cites W1507719842 @default.
- W2055097128 cites W1557478309 @default.
- W2055097128 cites W1605252096 @default.
- W2055097128 cites W1607745865 @default.
- W2055097128 cites W1681931564 @default.
- W2055097128 cites W1970030465 @default.
- W2055097128 cites W1979257234 @default.
- W2055097128 cites W1981655068 @default.
- W2055097128 cites W1982933055 @default.
- W2055097128 cites W1985666310 @default.
- W2055097128 cites W1993418815 @default.
- W2055097128 cites W2022638591 @default.
- W2055097128 cites W2036971484 @default.
- W2055097128 cites W2041797886 @default.
- W2055097128 cites W2041834434 @default.
- W2055097128 cites W2044713093 @default.
- W2055097128 cites W2056942156 @default.
- W2055097128 cites W2085418697 @default.
- W2055097128 cites W2090702802 @default.
- W2055097128 cites W2094660899 @default.
- W2055097128 cites W2098806204 @default.
- W2055097128 cites W2140733491 @default.
- W2055097128 cites W2156565205 @default.
- W2055097128 cites W2218331703 @default.
- W2055097128 cites W2320598133 @default.
- W2055097128 cites W2331143633 @default.
- W2055097128 cites W2416894777 @default.
- W2055097128 cites W2472210032 @default.
- W2055097128 cites W4232777855 @default.
- W2055097128 doi "https://doi.org/10.1073/pnas.90.6.2281" @default.
- W2055097128 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/46070" @default.
- W2055097128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8460134" @default.
- W2055097128 hasPublicationYear "1993" @default.
- W2055097128 type Work @default.
- W2055097128 sameAs 2055097128 @default.
- W2055097128 citedByCount "232" @default.
- W2055097128 countsByYear W20550971282012 @default.
- W2055097128 countsByYear W20550971282013 @default.
- W2055097128 countsByYear W20550971282014 @default.
- W2055097128 countsByYear W20550971282015 @default.
- W2055097128 countsByYear W20550971282016 @default.
- W2055097128 countsByYear W20550971282017 @default.
- W2055097128 countsByYear W20550971282018 @default.
- W2055097128 countsByYear W20550971282019 @default.
- W2055097128 countsByYear W20550971282020 @default.
- W2055097128 countsByYear W20550971282021 @default.
- W2055097128 countsByYear W20550971282022 @default.
- W2055097128 countsByYear W20550971282023 @default.
- W2055097128 crossrefType "journal-article" @default.
- W2055097128 hasAuthorship W2055097128A5012279033 @default.
- W2055097128 hasAuthorship W2055097128A5021949734 @default.
- W2055097128 hasAuthorship W2055097128A5024393250 @default.
- W2055097128 hasAuthorship W2055097128A5025349103 @default.
- W2055097128 hasAuthorship W2055097128A5026791776 @default.
- W2055097128 hasAuthorship W2055097128A5054135230 @default.
- W2055097128 hasAuthorship W2055097128A5058150457 @default.
- W2055097128 hasAuthorship W2055097128A5063363278 @default.
- W2055097128 hasAuthorship W2055097128A5066216857 @default.
- W2055097128 hasBestOaLocation W20550971282 @default.
- W2055097128 hasConcept C105702510 @default.
- W2055097128 hasConcept C112243037 @default.
- W2055097128 hasConcept C150757390 @default.
- W2055097128 hasConcept C181199279 @default.
- W2055097128 hasConcept C185592680 @default.
- W2055097128 hasConcept C2776990775 @default.
- W2055097128 hasConcept C2777576037 @default.
- W2055097128 hasConcept C2777827897 @default.
- W2055097128 hasConcept C2778022156 @default.
- W2055097128 hasConcept C2778396349 @default.
- W2055097128 hasConcept C2779222958 @default.
- W2055097128 hasConcept C2779707156 @default.
- W2055097128 hasConcept C2779716203 @default.
- W2055097128 hasConcept C2779920670 @default.
- W2055097128 hasConcept C523546767 @default.
- W2055097128 hasConcept C54355233 @default.
- W2055097128 hasConcept C55493867 @default.
- W2055097128 hasConcept C57790582 @default.
- W2055097128 hasConcept C62112901 @default.
- W2055097128 hasConcept C71240020 @default.
- W2055097128 hasConcept C86803240 @default.
- W2055097128 hasConceptScore W2055097128C105702510 @default.
- W2055097128 hasConceptScore W2055097128C112243037 @default.