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- W2055102759 abstract "Purpose To determine the effect of hyperthyroidism on both myofiber number and myosin heavy-chain isoform composition within the palpebral orbicularis oculi muscle in rabbits. Methods Four New Zealand White rabbits were made hyperthyroid by injection of 3,3,3′-triiodothyroinine intraperitoneally every other day for 1 month. Four rabbits were used as control animals. After 1 month the rabbits were euthanized, and the eyelids were excised and sectioned in a cryostat. The sections were immunostained to determine the presence of fast, slow, and neonatal myosin heavy-chain isoforms. To determine alterations in myofiber number, differential counts of myofiber number and the cross-sectional areas of the muscle fibers were performed with the use of computerized morphometry. Results The orbicularis oculi muscle in the palpebral portion of the eyelids from hyperthyroid rabbits had significantly fewer myofibers compared with control eyelids, predominantly as the result of a loss of myofibers in the preseptal region. The remaining fibers showed continued expression of fast myosin but upregulated coexpression of slow myosin isoform. Conclusions Hyperthyroidism led to reduced orbicularis oculi muscle in the rabbit model and an alteration in the myosin heavy-chain isoform composition. This finding may help explain the clinical finding of eyelid retraction in patients with Graves orbitopathy." @default.
- W2055102759 created "2016-06-24" @default.
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- W2055102759 date "2002-07-01" @default.
- W2055102759 modified "2023-10-17" @default.
- W2055102759 title "Effect of Hyperthyroidism on the Orbicularis Oculi Muscle in Rabbits" @default.
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- W2055102759 doi "https://doi.org/10.1097/00002341-200207000-00011" @default.
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