FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055103622> ?p ?o ?g. }

• W2055103622 abstract "Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DCThe purpose of the study is to identify markers that could define a robust signature discriminating case by case radiation-induced tumors from their sporadic counterparts. The rare occurrence of human radiation-induced tumors increases the difficulty of their identification. Nevertheless, in case of sarcomas occurring in the irradiation field after radiotherapy for a primary neoplasm, stringent criteria allow the radiation-induced etiology to be established with a high level of confidence. However, the available series remains limited. Global transcriptome studies are particularly affected by this problem since the methods used for data analysis are generally efficient only for long series. In order to solve this problem, we have developped new methods of classification, based on transcriptome analysis, for the case by case tumor diagnosis. To find a signature we first select a set of candidate genes, using Expectation-Maximisation algorithm, on a learning set of tumors. Second, using a training set of tumors, we select the genes with the higher potential for classifying the tumors. Then, the robustness of the signature was tested by blindly classifying an independent set of tumors.Using a learning/training set of 12 radiation-induced (RI) and 12 sporadic (SP) sarcomas including angiosarcomas, leiomyosarcomas and osteosarcomas, we identified a minimal signature of 143 genes discriminating the sarcomas according to the etiology. A larger signature of 1100 genes, using less stringent criteria of classification was also established. The robustness of these signatures was tested by the blindly case by case classification of an independent set of 22 RI and 14 SP sarcomas of various histologies. After the histology code-break, 28/36 sarcomas were well-classified using the minimal signature, in 6 cases (1 RI and 5 SP) the etiology could not be established whereas 2 SP sarcomas were classified as RI. Using the large signature, the etiology was not determined in 4 cases (1 RI and 3 SP) and the 32 other sarcomas were well-classified. Several pathway were found differentially expressed according to the etiology. Notably, the NRF2-mediated oxidative stress response pathway, the ubiquitination-deubiquitination pathways and several genes coding subunits of the 26S proteasome and heat shock proteins underwent a general up regulation in RI sarcomas. These data suggest that RI sarcomas are submitted to oxidative stress that could generate the formation of mis-folded and oxidated proteins further degradated by the ubiquitination-deubiquitination-proteasome pathway. In this study, we identify a robust signature discriminating radiation-induced from sporadic sarcomas, opening the possibility to recognise, case by case, the implication of ionizing radiation in a tumor formation.Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5636." @default.
• W2055103622 created "2016-06-24" @default.
• W2055103622 creator A5004410076 @default.
• W2055103622 creator A5009811729 @default.
• W2055103622 creator A5044212009 @default.
• W2055103622 creator A5085842128 @default.
• W2055103622 creator A5091297860 @default.
• W2055103622 date "2010-04-15" @default.
• W2055103622 modified "2023-09-27" @default.
• W2055103622 title "Abstract 5636: Gene expression signature discriminates sporadic from post-radiotherapy radiation-induced sarcomas" @default.
• W2055103622 doi "https://doi.org/10.1158/1538-7445.am10-5636" @default.
• W2055103622 hasPublicationYear "2010" @default.
• W2055103622 type Work @default.
• W2055103622 sameAs 2055103622 @default.
• W2055103622 citedByCount "0" @default.
• W2055103622 crossrefType "proceedings-article" @default.
• W2055103622 hasAuthorship W2055103622A5004410076 @default.
• W2055103622 hasAuthorship W2055103622A5009811729 @default.
• W2055103622 hasAuthorship W2055103622A5044212009 @default.
• W2055103622 hasAuthorship W2055103622A5085842128 @default.
• W2055103622 hasAuthorship W2055103622A5091297860 @default.
• W2055103622 hasConcept C104317684 @default.
• W2055103622 hasConcept C121608353 @default.
• W2055103622 hasConcept C126322002 @default.
• W2055103622 hasConcept C126838900 @default.
• W2055103622 hasConcept C142724271 @default.
• W2055103622 hasConcept C150194340 @default.
• W2055103622 hasConcept C162317418 @default.
• W2055103622 hasConcept C2778256501 @default.
• W2055103622 hasConcept C2779733811 @default.
• W2055103622 hasConcept C509974204 @default.
• W2055103622 hasConcept C54355233 @default.
• W2055103622 hasConcept C60644358 @default.
• W2055103622 hasConcept C63479239 @default.
• W2055103622 hasConcept C70721500 @default.
• W2055103622 hasConcept C71924100 @default.
• W2055103622 hasConcept C86803240 @default.
• W2055103622 hasConceptScore W2055103622C104317684 @default.
• W2055103622 hasConceptScore W2055103622C121608353 @default.
• W2055103622 hasConceptScore W2055103622C126322002 @default.
• W2055103622 hasConceptScore W2055103622C126838900 @default.
• W2055103622 hasConceptScore W2055103622C142724271 @default.
• W2055103622 hasConceptScore W2055103622C150194340 @default.
• W2055103622 hasConceptScore W2055103622C162317418 @default.
• W2055103622 hasConceptScore W2055103622C2778256501 @default.
• W2055103622 hasConceptScore W2055103622C2779733811 @default.
• W2055103622 hasConceptScore W2055103622C509974204 @default.
• W2055103622 hasConceptScore W2055103622C54355233 @default.
• W2055103622 hasConceptScore W2055103622C60644358 @default.
• W2055103622 hasConceptScore W2055103622C63479239 @default.
• W2055103622 hasConceptScore W2055103622C70721500 @default.
• W2055103622 hasConceptScore W2055103622C71924100 @default.
• W2055103622 hasConceptScore W2055103622C86803240 @default.
• W2055103622 hasLocation W20551036221 @default.
• W2055103622 hasOpenAccess W2055103622 @default.
• W2055103622 hasPrimaryLocation W20551036221 @default.
• W2055103622 hasRelatedWork W1524601355 @default.
• W2055103622 hasRelatedWork W1966956875 @default.
• W2055103622 hasRelatedWork W1991375897 @default.
• W2055103622 hasRelatedWork W1998912372 @default.
• W2055103622 hasRelatedWork W2064895864 @default.
• W2055103622 hasRelatedWork W2091309870 @default.
• W2055103622 hasRelatedWork W2102543299 @default.
• W2055103622 hasRelatedWork W2325022558 @default.
• W2055103622 hasRelatedWork W2327457770 @default.
• W2055103622 hasRelatedWork W2332397502 @default.
• W2055103622 hasRelatedWork W2403189961 @default.
• W2055103622 hasRelatedWork W2799523421 @default.
• W2055103622 hasRelatedWork W2915554894 @default.
• W2055103622 hasRelatedWork W2981978164 @default.
• W2055103622 hasRelatedWork W3083274533 @default.
• W2055103622 hasRelatedWork W3095577569 @default.
• W2055103622 hasRelatedWork W3114842744 @default.
• W2055103622 hasRelatedWork W3201728939 @default.
• W2055103622 hasRelatedWork W3213984724 @default.
• W2055103622 hasRelatedWork W3214299643 @default.
• W2055103622 isParatext "false" @default.
• W2055103622 isRetracted "false" @default.
• W2055103622 magId "2055103622" @default.
• W2055103622 workType "article" @default.