FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055103634> ?p ?o ?g. }

• W2055103634 endingPage "445" @default.
• W2055103634 startingPage "441" @default.
• W2055103634 abstract "It has been reported that the in vivo maturation of Langerhans cells after hapten painting is mediated by IL-1 beta while Langerhans cell maturation after in vitro culture is mediated by granulocyte-macrophage colony-stimulating factor (GM-CSF). To clarify the reason for this discrepancy, we examine the expression of Ia antigen and several co-stimulatory molecules on Langerhans cells that were activated by in vitro culture, by hapten painting, or by an intradermal injection of several cytokines. Both cultured Langerhans cells and those activated by hapten painting increased the expression of Ia antigen and all the co-stimulatory molecules (i.e., intercellular adhesion molecule-1 [ICAM-1], B7-1, B7-2, and CD40). In contrast, an intradermal injection of interleukin-1 beta (IL-1 beta) or tumor necrosis factor-alpha (TNF-alpha) increased the expression of Ia antigen, ICAM-1, B7-2, and CD40, but not that of B7-1. These data indicate that IL-1 beta or TNF-alpha is not sufficient to induce B7-1 expression on Langerhans cells in vivo. Subsequently we examined the effect of anti-cytokine antibodies (Abs) on the expression of those molecules on cultured Langerhans cells. While none of the Abs to IL-1 beta, TNF-alpha, or GM-CSF changed the upregulation of Ia antigen, ICAM-1, or CD40 on cultured Langerhans cells, anti-GM-CSF Ab suppressed that of B7-1 and B7-2. Taken together, our present results suggest that IL-1 beta is required for the upregulation of Ia, ICAM-1, B7-2, and CD40, while GM-CSF is required for the upregulation of B7-1 and B7-2, although it still remains unclear why the injected GM-CSF could not augment B7-1 expression on Langerhans cells in vivo and why anti-IL-1 beta Ab did not suppress the upregulation of Ia, ICAM-1, or CD40 on cultured Langerhans cells." @default.
• W2055103634 created "2016-06-24" @default.
• W2055103634 creator A5012976720 @default.
• W2055103634 creator A5046865187 @default.
• W2055103634 creator A5059911951 @default.
• W2055103634 creator A5075350569 @default.
• W2055103634 date "1996-03-01" @default.
• W2055103634 modified "2023-09-26" @default.
• W2055103634 title "Interleukin-1β and Granulocyte-Macrophage Colony-Stimulating Factor Mediate Langerhans Cell Maturation Differently" @default.
• W2055103634 cites W1505516118 @default.
• W2055103634 cites W1513900203 @default.
• W2055103634 cites W1527531781 @default.
• W2055103634 cites W1548317256 @default.
• W2055103634 cites W1549471106 @default.
• W2055103634 cites W1562057469 @default.
• W2055103634 cites W1581966627 @default.
• W2055103634 cites W1966286149 @default.
• W2055103634 cites W1966842062 @default.
• W2055103634 cites W1970570766 @default.
• W2055103634 cites W1983601075 @default.
• W2055103634 cites W2000517438 @default.
• W2055103634 cites W2004700644 @default.
• W2055103634 cites W2009914165 @default.
• W2055103634 cites W2010350911 @default.
• W2055103634 cites W2035552180 @default.
• W2055103634 cites W2053513233 @default.
• W2055103634 cites W2053719727 @default.
• W2055103634 cites W2054703329 @default.
• W2055103634 cites W2057161597 @default.
• W2055103634 cites W2059067233 @default.
• W2055103634 cites W2080310980 @default.
• W2055103634 cites W2088746342 @default.
• W2055103634 cites W2092493402 @default.
• W2055103634 cites W2096152012 @default.
• W2055103634 cites W2100117872 @default.
• W2055103634 cites W2110340781 @default.
• W2055103634 cites W2121604038 @default.
• W2055103634 cites W2125630736 @default.
• W2055103634 cites W2127727516 @default.
• W2055103634 cites W2131761283 @default.
• W2055103634 cites W2135272173 @default.
• W2055103634 doi "https://doi.org/10.1111/1523-1747.ep12343589" @default.
• W2055103634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8648174" @default.
• W2055103634 hasPublicationYear "1996" @default.
• W2055103634 type Work @default.
• W2055103634 sameAs 2055103634 @default.
• W2055103634 citedByCount "94" @default.
• W2055103634 countsByYear W20551036342012 @default.
• W2055103634 countsByYear W20551036342014 @default.
• W2055103634 countsByYear W20551036342015 @default.
• W2055103634 countsByYear W20551036342017 @default.
• W2055103634 countsByYear W20551036342018 @default.
• W2055103634 countsByYear W20551036342019 @default.
• W2055103634 countsByYear W20551036342020 @default.
• W2055103634 countsByYear W20551036342021 @default.
• W2055103634 crossrefType "journal-article" @default.
• W2055103634 hasAuthorship W2055103634A5012976720 @default.
• W2055103634 hasAuthorship W2055103634A5046865187 @default.
• W2055103634 hasAuthorship W2055103634A5059911951 @default.
• W2055103634 hasAuthorship W2055103634A5075350569 @default.
• W2055103634 hasBestOaLocation W20551036341 @default.
• W2055103634 hasConcept C147483822 @default.
• W2055103634 hasConcept C153911025 @default.
• W2055103634 hasConcept C154317977 @default.
• W2055103634 hasConcept C16224149 @default.
• W2055103634 hasConcept C17991360 @default.
• W2055103634 hasConcept C185592680 @default.
• W2055103634 hasConcept C202751555 @default.
• W2055103634 hasConcept C203014093 @default.
• W2055103634 hasConcept C2777478134 @default.
• W2055103634 hasConcept C2778379841 @default.
• W2055103634 hasConcept C2778690821 @default.
• W2055103634 hasConcept C39347974 @default.
• W2055103634 hasConcept C55493867 @default.
• W2055103634 hasConcept C86803240 @default.
• W2055103634 hasConceptScore W2055103634C147483822 @default.
• W2055103634 hasConceptScore W2055103634C153911025 @default.
• W2055103634 hasConceptScore W2055103634C154317977 @default.
• W2055103634 hasConceptScore W2055103634C16224149 @default.
• W2055103634 hasConceptScore W2055103634C17991360 @default.
• W2055103634 hasConceptScore W2055103634C185592680 @default.
• W2055103634 hasConceptScore W2055103634C202751555 @default.
• W2055103634 hasConceptScore W2055103634C203014093 @default.
• W2055103634 hasConceptScore W2055103634C2777478134 @default.
• W2055103634 hasConceptScore W2055103634C2778379841 @default.
• W2055103634 hasConceptScore W2055103634C2778690821 @default.
• W2055103634 hasConceptScore W2055103634C39347974 @default.
• W2055103634 hasConceptScore W2055103634C55493867 @default.
• W2055103634 hasConceptScore W2055103634C86803240 @default.
• W2055103634 hasIssue "3" @default.
• W2055103634 hasLocation W20551036341 @default.
• W2055103634 hasLocation W20551036342 @default.
• W2055103634 hasOpenAccess W2055103634 @default.
• W2055103634 hasPrimaryLocation W20551036341 @default.
• W2055103634 hasRelatedWork W1494014013 @default.
• W2055103634 hasRelatedWork W1994050787 @default.
• W2055103634 hasRelatedWork W2006549602 @default.
• W2055103634 hasRelatedWork W2020821867 @default.

• next