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- W2055105172 abstract "A general question in development is how do adjacent primordia adopt different developmental fates and stably maintain their distinct fates? In Drosophila melanogaster, the adult eye and antenna originate from the embryonic eye-antenna primordium. These cells proliferate in the larval stage to form the eye-antenna disc. The eye or antenna differs at mid second instar with the restricted expression of Cut (Ct), a homeodomain transcriptional repressor, in the antenna disc and Eyeless (Ey), a Pax6 transcriptional activator, in the eye disc. In this study, we show that ey transcription in the antenna disc is repressed by two homeodomain proteins, Ct and Homothorax (Hth). Loss of Ct and Hth in the antenna disc resulted in ectopic eye development in the antenna. Conversely, the Ct and Hth expression in the eye disc was suppressed by the homeodomain transcription factor Sine oculis (So), a direct target of Ey. Loss of So in the eye disc caused ectopic antenna development in the eye. Therefore, the segregation of eye and antenna fates is stably maintained by mutual repression of the other pathway." @default.
- W2055105172 created "2016-06-24" @default.
- W2055105172 creator A5028325404 @default.
- W2055105172 creator A5067668992 @default.
- W2055105172 date "2012-09-15" @default.
- W2055105172 modified "2023-09-27" @default.
- W2055105172 title "Segregation of eye and antenna fates maintained by mutual antagonism in <i>Drosophila</i>" @default.
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- W2055105172 doi "https://doi.org/10.1242/dev.078857" @default.
- W2055105172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22912416" @default.
- W2055105172 hasPublicationYear "2012" @default.
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