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• W2055109779 abstract "The plants used in Ayurvedic medicine, which has been practiced in India for thousands of years for the treatment of a variety of disorders, are rich in chemicals potentially useful for prevention and treatment of cancer. Withania somnifera (commonly known as Ashwagandha in Ayurvedic medicine) is one such medicinal plant whose anticancer value was realized over four decades ago after isolation of a crystalline steroidal compound (withaferin A) from the leaves of this shrub. The root and leaf extracts of W. somnifera are shown to confer protection against chemically-induced cancers in experimental rodents, and retard tumor xenograft growth in athymic mice. Anticancer effect of W. somnifera is generally attributable to steroidal lactones collectively referred to as withanolides. Withaferin A (WA) appears most active against cancer among structurally divergent withanolides isolated from the root or leaf of W. somnifera. Cancer-protective role for WA has now been established using chemically-induced and oncogene-driven rodent cancer models. This review summarizes the key in vivo preclinical studies demonstrating anticancer effects of WA. Molecular targets and mechanisms likely contributing to the anticancer effects of WA are also discussed. Finally, challenges in clinical development of WA for the prevention and treatment of cancer are highlighted." @default.
• W2055109779 created "2016-06-24" @default.
• W2055109779 creator A5022304953 @default.
• W2055109779 creator A5048690318 @default.
• W2055109779 date "2013-09-18" @default.
• W2055109779 modified "2023-10-10" @default.
• W2055109779 title "Molecular Targets and Mechanisms of Cancer Prevention and Treatment by Withaferin A, A Naturally Occurring Steroidal Lactone" @default.
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• W2055109779 doi "https://doi.org/10.1208/s12248-013-9531-1" @default.
• W2055109779 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3889529" @default.
• W2055109779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24046237" @default.
• W2055109779 hasPublicationYear "2013" @default.
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