Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055117730> ?p ?o ?g. }
- W2055117730 endingPage "274" @default.
- W2055117730 startingPage "262" @default.
- W2055117730 abstract "Sonic hedgehog (Shh) signaling is required for numerous developmental processes including specification of ventral cell types in the central nervous system such as midbrain dopaminergic (DA) neurons. The multifunctional coreceptor Cdo increases the signaling activity of Shh which is crucial for development of forebrain and neural tube. In this study, we investigated the role of Cdo in midbrain DA neurogenesis. Cdo and Shh signaling components are induced during neurogenesis of embryonic stem (ES) cells. Cdo(-/-) ES cells show reduced neuronal differentiation accompanied by increased cell death upon neuronal induction. In addition, Cdo(-/-) ES cells form fewer tyrosine hydroxylase (TH) and microtubule associated protein 2 (MAP2)-positive DA neurons correlating with the decreased expression of key regulators of DA neurogenesis, such as Shh, Neurogenin2, Mash1, Foxa2, Lmx1a, Nurr1 and Pitx3, relative to the Cdo(+/+) ES cells. Consistently, the Cdo(-/-) embryonic midbrain displays a reduction in expression of TH and Nurr1. Furthermore, activation of Shh signaling by treatment with Purmorphamine (Pur) restores the DA neurogenesis of Cdo(-/-) ES cells, suggesting that Cdo is required for the full Shh signaling activation to induce efficient DA neurogenesis." @default.
- W2055117730 created "2016-06-24" @default.
- W2055117730 creator A5000561668 @default.
- W2055117730 creator A5026339029 @default.
- W2055117730 creator A5038756143 @default.
- W2055117730 creator A5055732430 @default.
- W2055117730 creator A5059892393 @default.
- W2055117730 creator A5070166530 @default.
- W2055117730 creator A5084900872 @default.
- W2055117730 date "2014-09-01" @default.
- W2055117730 modified "2023-10-15" @default.
- W2055117730 title "The Shh coreceptor Cdo is required for differentiation of midbrain dopaminergic neurons" @default.
- W2055117730 cites W1507664203 @default.
- W2055117730 cites W1927606887 @default.
- W2055117730 cites W1972579549 @default.
- W2055117730 cites W1974280015 @default.
- W2055117730 cites W1995626795 @default.
- W2055117730 cites W2005487923 @default.
- W2055117730 cites W2006655453 @default.
- W2055117730 cites W2009266031 @default.
- W2055117730 cites W2011070056 @default.
- W2055117730 cites W2014077626 @default.
- W2055117730 cites W2016249661 @default.
- W2055117730 cites W2021258728 @default.
- W2055117730 cites W2027177102 @default.
- W2055117730 cites W2027969818 @default.
- W2055117730 cites W2034603498 @default.
- W2055117730 cites W2043927239 @default.
- W2055117730 cites W2052302258 @default.
- W2055117730 cites W2059674642 @default.
- W2055117730 cites W2062118486 @default.
- W2055117730 cites W2065253927 @default.
- W2055117730 cites W2074145762 @default.
- W2055117730 cites W2075305901 @default.
- W2055117730 cites W2075453897 @default.
- W2055117730 cites W2086046051 @default.
- W2055117730 cites W2090661065 @default.
- W2055117730 cites W2091577669 @default.
- W2055117730 cites W2104033956 @default.
- W2055117730 cites W2107658317 @default.
- W2055117730 cites W2109105290 @default.
- W2055117730 cites W2111525324 @default.
- W2055117730 cites W2112877380 @default.
- W2055117730 cites W2117763311 @default.
- W2055117730 cites W2127983231 @default.
- W2055117730 cites W2130128490 @default.
- W2055117730 cites W2136440581 @default.
- W2055117730 cites W2138775922 @default.
- W2055117730 cites W2138979073 @default.
- W2055117730 cites W2143819718 @default.
- W2055117730 cites W2148195823 @default.
- W2055117730 cites W2154069538 @default.
- W2055117730 cites W2162545048 @default.
- W2055117730 cites W2164983140 @default.
- W2055117730 cites W2165671896 @default.
- W2055117730 cites W2168967248 @default.
- W2055117730 cites W2170467682 @default.
- W2055117730 cites W2172099438 @default.
- W2055117730 cites W49996880 @default.
- W2055117730 doi "https://doi.org/10.1016/j.scr.2014.07.004" @default.
- W2055117730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25117422" @default.
- W2055117730 hasPublicationYear "2014" @default.
- W2055117730 type Work @default.
- W2055117730 sameAs 2055117730 @default.
- W2055117730 citedByCount "13" @default.
- W2055117730 countsByYear W20551177302016 @default.
- W2055117730 countsByYear W20551177302017 @default.
- W2055117730 countsByYear W20551177302018 @default.
- W2055117730 countsByYear W20551177302019 @default.
- W2055117730 countsByYear W20551177302020 @default.
- W2055117730 countsByYear W20551177302021 @default.
- W2055117730 countsByYear W20551177302022 @default.
- W2055117730 countsByYear W20551177302023 @default.
- W2055117730 crossrefType "journal-article" @default.
- W2055117730 hasAuthorship W2055117730A5000561668 @default.
- W2055117730 hasAuthorship W2055117730A5026339029 @default.
- W2055117730 hasAuthorship W2055117730A5038756143 @default.
- W2055117730 hasAuthorship W2055117730A5055732430 @default.
- W2055117730 hasAuthorship W2055117730A5059892393 @default.
- W2055117730 hasAuthorship W2055117730A5070166530 @default.
- W2055117730 hasAuthorship W2055117730A5084900872 @default.
- W2055117730 hasBestOaLocation W20551177301 @default.
- W2055117730 hasConcept C104317684 @default.
- W2055117730 hasConcept C126322002 @default.
- W2055117730 hasConcept C134018914 @default.
- W2055117730 hasConcept C136834591 @default.
- W2055117730 hasConcept C137183658 @default.
- W2055117730 hasConcept C145103041 @default.
- W2055117730 hasConcept C148738053 @default.
- W2055117730 hasConcept C159167319 @default.
- W2055117730 hasConcept C169760540 @default.
- W2055117730 hasConcept C2776637008 @default.
- W2055117730 hasConcept C2779715522 @default.
- W2055117730 hasConcept C28328180 @default.
- W2055117730 hasConcept C4746552 @default.
- W2055117730 hasConcept C513476851 @default.
- W2055117730 hasConcept C529278444 @default.
- W2055117730 hasConcept C552161191 @default.