FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055117961> ?p ?o ?g. }

• W2055117961 endingPage "59" @default.
• W2055117961 startingPage "52" @default.
• W2055117961 abstract "The aim of this study was to develop a limited sampling strategy to allow the simultaneous estimation of the area under the concentration-time curves (AUCs) of tacrolimus and mycophenolic acid (MPA), the active metabolite of the prodrug mycophenolate mofetil, using a small number of samples from patients undergoing renal transplantation. Fifty Japanese patients were enrolled. On day 28 after transplantation, samples were collected just before and 1, 2, 3, 4, 6, 9, and 12 hours after tacrolimus and mycophenolate mofetil administration at 9:00 am and 9:00 pm. The full pharmacokinetic profiles obtained from these timed concentration data were used to choose the best sampling times. Three error indices (percent mean error, percent mean absolute error, and percent relative mean square error) were used to evaluate the predictive bias, accuracy, and precision. The predicted AUC0-12 of MPA calculated at the three time points of C2h-C4h-C9h best approximated the actual AUC0-12 of MPA (r2 = 0.877), and the AUC0-12 of tacrolimus calculated at the same time points predicted a good correlation with the actual AUC (r2 = 0.928). When the three sampling times of trough level (C0h) and two other points within 4 hours after administration were used, the three points of C0h-C2h-C4h were the best points for estimation of the AUC0-12 tacrolimus and MPA (AUC0-12 = 7.04·C0 + 1.71·C2 + 3.23·C4 + 15.19, r2 = 0.799, P < 0.001 and AUC0-12 = 0.26·C0 + 2.06·C2 + 3.82·C4 + 20.38, r2 = 0.693, P < 0.001, respectively). The percent mean error, percent mean absolute error, and percent relative mean square error of the prediction formula using the three time points of C0h-C2h-C4h were -0.3%, 8.8%, and 13.5% for tacrolimus and 2.9%, 17.1%, and 21.5% for MPA, respectively. A limited sampling strategy using C2h-C4h-C9h provides the most reliable and accurate simultaneous estimation of the AUC0-12 of tacrolimus and MPA in patients undergoing renal transplantation. In addition, a limited sampling strategy using C0h-C2h-C4h is recommended for the simultaneous estimation of the AUC0-12 of tacrolimus and MPA when focused on samples collected within 4 hours after administration for clinical expediency." @default.
• W2055117961 created "2016-06-24" @default.
• W2055117961 creator A5012066043 @default.
• W2055117961 creator A5055730891 @default.
• W2055117961 creator A5060639082 @default.
• W2055117961 creator A5064286836 @default.
• W2055117961 creator A5070286501 @default.
• W2055117961 creator A5073793600 @default.
• W2055117961 creator A5086680208 @default.
• W2055117961 creator A5089208654 @default.
• W2055117961 date "2008-02-01" @default.
• W2055117961 modified "2023-09-30" @default.
• W2055117961 title "Limited Sampling Strategy for Simultaneous Estimation of the Area Under the Concentration-Time Curve of Tacrolimus and Mycophenolic Acid in Adult Renal Transplant Recipients" @default.
• W2055117961 cites W1567403209 @default.
• W2055117961 cites W1964887178 @default.
• W2055117961 cites W1970306408 @default.
• W2055117961 cites W1971018450 @default.
• W2055117961 cites W1978730624 @default.
• W2055117961 cites W1979531247 @default.
• W2055117961 cites W1981535286 @default.
• W2055117961 cites W1981801952 @default.
• W2055117961 cites W1992303861 @default.
• W2055117961 cites W1994092210 @default.
• W2055117961 cites W1996001672 @default.
• W2055117961 cites W2001349326 @default.
• W2055117961 cites W2001677024 @default.
• W2055117961 cites W2003143162 @default.
• W2055117961 cites W2013783025 @default.
• W2055117961 cites W2016100084 @default.
• W2055117961 cites W2021587245 @default.
• W2055117961 cites W2025501899 @default.
• W2055117961 cites W2027275750 @default.
• W2055117961 cites W2027774666 @default.
• W2055117961 cites W2028641895 @default.
• W2055117961 cites W2037296911 @default.
• W2055117961 cites W2037341390 @default.
• W2055117961 cites W2037681070 @default.
• W2055117961 cites W2056054156 @default.
• W2055117961 cites W2056566781 @default.
• W2055117961 cites W2068650301 @default.
• W2055117961 cites W2072486418 @default.
• W2055117961 cites W2083466825 @default.
• W2055117961 cites W2088942316 @default.
• W2055117961 cites W2107772973 @default.
• W2055117961 cites W2139801021 @default.
• W2055117961 cites W2150895558 @default.
• W2055117961 cites W2315537783 @default.
• W2055117961 cites W2335210339 @default.
• W2055117961 cites W2409639874 @default.
• W2055117961 doi "https://doi.org/10.1097/ftd.0b013e31815f5416" @default.
• W2055117961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18223463" @default.
• W2055117961 hasPublicationYear "2008" @default.
• W2055117961 type Work @default.
• W2055117961 sameAs 2055117961 @default.
• W2055117961 citedByCount "45" @default.
• W2055117961 countsByYear W20551179612012 @default.
• W2055117961 countsByYear W20551179612013 @default.
• W2055117961 countsByYear W20551179612014 @default.
• W2055117961 countsByYear W20551179612015 @default.
• W2055117961 countsByYear W20551179612016 @default.
• W2055117961 countsByYear W20551179612017 @default.
• W2055117961 countsByYear W20551179612018 @default.
• W2055117961 countsByYear W20551179612021 @default.
• W2055117961 countsByYear W20551179612022 @default.
• W2055117961 crossrefType "journal-article" @default.
• W2055117961 hasAuthorship W2055117961A5012066043 @default.
• W2055117961 hasAuthorship W2055117961A5055730891 @default.
• W2055117961 hasAuthorship W2055117961A5060639082 @default.
• W2055117961 hasAuthorship W2055117961A5064286836 @default.
• W2055117961 hasAuthorship W2055117961A5070286501 @default.
• W2055117961 hasAuthorship W2055117961A5073793600 @default.
• W2055117961 hasAuthorship W2055117961A5086680208 @default.
• W2055117961 hasAuthorship W2055117961A5089208654 @default.
• W2055117961 hasConcept C105795698 @default.
• W2055117961 hasConcept C106131492 @default.
• W2055117961 hasConcept C108215921 @default.
• W2055117961 hasConcept C112705442 @default.
• W2055117961 hasConcept C126322002 @default.
• W2055117961 hasConcept C126894567 @default.
• W2055117961 hasConcept C140779682 @default.
• W2055117961 hasConcept C2778033501 @default.
• W2055117961 hasConcept C2909675724 @default.
• W2055117961 hasConcept C2909935303 @default.
• W2055117961 hasConcept C2911091166 @default.
• W2055117961 hasConcept C31972630 @default.
• W2055117961 hasConcept C33923547 @default.
• W2055117961 hasConcept C41008148 @default.
• W2055117961 hasConcept C71924100 @default.
• W2055117961 hasConcept C76318530 @default.
• W2055117961 hasConcept C98274493 @default.
• W2055117961 hasConceptScore W2055117961C105795698 @default.
• W2055117961 hasConceptScore W2055117961C106131492 @default.
• W2055117961 hasConceptScore W2055117961C108215921 @default.
• W2055117961 hasConceptScore W2055117961C112705442 @default.
• W2055117961 hasConceptScore W2055117961C126322002 @default.
• W2055117961 hasConceptScore W2055117961C126894567 @default.
• W2055117961 hasConceptScore W2055117961C140779682 @default.
• W2055117961 hasConceptScore W2055117961C2778033501 @default.

• next