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- W2055125087 abstract "Biodegradable microspheres were fabricated by poly(ɛ-caprolactone) (PCL) homopolymer and poly(ɛ-caprolactone-b-ethylene oxide) (PCL-b-PEO) amphiphilic block copolymer. The regulation of microsphere surface morphology was successfully achieved by controlled enzymatic degradation. The morphological changes induced by biodegradation and their influences on the growth of MG-63 human osteosarcoma cells were studied. Results based on the evaluation of cytotoxicity and the morphological observation of MG-63 cells cultivated on microspheres showed better growth of cells on the surface of degraded microspheres than on the surface of those undegraded microspheres no matter they were fabricated by homopolymers or copolymers. The influences of morphological changes of microsphere surface before and after biodegradation on MG-63 cell growth were discussed. The results of this work indicated that the biodegradation-induced morphological changes of microspheres could be well controlled and were favorable for MG-63 cell attachment and proliferation." @default.
- W2055125087 created "2016-06-24" @default.
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- W2055125087 date "2010-08-01" @default.
- W2055125087 modified "2023-10-07" @default.
- W2055125087 title "Biodegradation-induced surface change of polymer microspheres and its influence on cell growth" @default.
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- W2055125087 doi "https://doi.org/10.1016/j.polymdegradstab.2010.01.025" @default.
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