Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055127611> ?p ?o ?g. }
- W2055127611 endingPage "259" @default.
- W2055127611 startingPage "224" @default.
- W2055127611 abstract "Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) characterized by demyelination, with a relative sparing of axons. In MS patients, many neurologic signs and symptoms have been attributed to the underlying conduction deficits. The idea that neurologic function might be improved if conduction could be restored in CNS demyelinated axons led to the testing of potassium (K(+)) channel blockers as a symptomatic treatment. To date, only 2 broad-spectrum K(+) channel blockers, 4-aminopyridine (4-AP) and 3,4-diaminopyridine (3,4-DAP), have been tested in MS patients. Although both 4-AP and 3,4-DAP produce clear neurologic benefits, their use has been limited by toxicity. Here we review the current status of basic science and clinical research related to the therapeutic targeting of voltage-gated K(+) channels (K(v)) in MS. By bringing together 3 distinct but interrelated disciplines, we aim to provide perspective on a vast body of work highlighting the lengthy and ongoing process entailed in translating fundamental K(v) channel knowledge into new clinical treatments for patients with MS and other demyelinating diseases. Covered are (1) K(v) channel nomenclature, structure, function, and pharmacology; (2) classic and current experimental morphology and neurophysiology studies of demyelination and conduction deficits; and (3) a comprehensive overview of clinical trials utilizing 4-AP and 3,4-DAP in MS patients." @default.
- W2055127611 created "2016-06-24" @default.
- W2055127611 creator A5053659607 @default.
- W2055127611 creator A5059636539 @default.
- W2055127611 date "2006-07-01" @default.
- W2055127611 modified "2023-10-11" @default.
- W2055127611 title "Potassium channel blockers in multiple sclerosis: Neuronal Kv channels and effects of symptomatic treatment" @default.
- W2055127611 cites W124521728 @default.
- W2055127611 cites W1481507011 @default.
- W2055127611 cites W1487241851 @default.
- W2055127611 cites W1524865348 @default.
- W2055127611 cites W1542012362 @default.
- W2055127611 cites W1543610712 @default.
- W2055127611 cites W1558096813 @default.
- W2055127611 cites W1589854409 @default.
- W2055127611 cites W161931647 @default.
- W2055127611 cites W1640985392 @default.
- W2055127611 cites W1664511950 @default.
- W2055127611 cites W1830737945 @default.
- W2055127611 cites W1847339443 @default.
- W2055127611 cites W1869734513 @default.
- W2055127611 cites W1885378673 @default.
- W2055127611 cites W1911071268 @default.
- W2055127611 cites W1935182457 @default.
- W2055127611 cites W1940873746 @default.
- W2055127611 cites W1947481567 @default.
- W2055127611 cites W1964247198 @default.
- W2055127611 cites W1964501667 @default.
- W2055127611 cites W1964879289 @default.
- W2055127611 cites W1965593592 @default.
- W2055127611 cites W1966447027 @default.
- W2055127611 cites W1966667742 @default.
- W2055127611 cites W1966815375 @default.
- W2055127611 cites W1966844020 @default.
- W2055127611 cites W1967044686 @default.
- W2055127611 cites W1967297467 @default.
- W2055127611 cites W1969198078 @default.
- W2055127611 cites W1969239953 @default.
- W2055127611 cites W1969870358 @default.
- W2055127611 cites W1970078484 @default.
- W2055127611 cites W1970431690 @default.
- W2055127611 cites W1970525260 @default.
- W2055127611 cites W1970930847 @default.
- W2055127611 cites W1971505882 @default.
- W2055127611 cites W1971646616 @default.
- W2055127611 cites W1971880089 @default.
- W2055127611 cites W1971880850 @default.
- W2055127611 cites W1972116208 @default.
- W2055127611 cites W1972262740 @default.
- W2055127611 cites W1972603729 @default.
- W2055127611 cites W1972679916 @default.
- W2055127611 cites W1972882396 @default.
- W2055127611 cites W1973670013 @default.
- W2055127611 cites W1974447707 @default.
- W2055127611 cites W1975424106 @default.
- W2055127611 cites W1975744071 @default.
- W2055127611 cites W1975965227 @default.
- W2055127611 cites W1976267307 @default.
- W2055127611 cites W1976763631 @default.
- W2055127611 cites W1977407477 @default.
- W2055127611 cites W1979103094 @default.
- W2055127611 cites W1979334130 @default.
- W2055127611 cites W1979693042 @default.
- W2055127611 cites W1981921792 @default.
- W2055127611 cites W1982473946 @default.
- W2055127611 cites W1982927477 @default.
- W2055127611 cites W1983208767 @default.
- W2055127611 cites W1983365628 @default.
- W2055127611 cites W1983519301 @default.
- W2055127611 cites W1983540442 @default.
- W2055127611 cites W1983774046 @default.
- W2055127611 cites W1984175906 @default.
- W2055127611 cites W1984277152 @default.
- W2055127611 cites W1984417726 @default.
- W2055127611 cites W1984435018 @default.
- W2055127611 cites W1984445978 @default.
- W2055127611 cites W1985940938 @default.
- W2055127611 cites W1986872525 @default.
- W2055127611 cites W1987238410 @default.
- W2055127611 cites W1987499148 @default.
- W2055127611 cites W1987877477 @default.
- W2055127611 cites W1988614248 @default.
- W2055127611 cites W1989624644 @default.
- W2055127611 cites W1989723044 @default.
- W2055127611 cites W1989736892 @default.
- W2055127611 cites W1991328938 @default.
- W2055127611 cites W1991834239 @default.
- W2055127611 cites W1992319989 @default.
- W2055127611 cites W1993460694 @default.
- W2055127611 cites W1994805414 @default.
- W2055127611 cites W1995192578 @default.
- W2055127611 cites W1995380719 @default.
- W2055127611 cites W1996174238 @default.
- W2055127611 cites W1996607415 @default.
- W2055127611 cites W1997311117 @default.
- W2055127611 cites W1997346926 @default.
- W2055127611 cites W1997594148 @default.
- W2055127611 cites W1998588798 @default.