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• W2055131488 abstract "Interferon-alpha (IFNα)-associated mood disorder is a major complication of treatment for chronic hepatitis C. The authors report on three patients infected with chronic hepatitis C showing severe depressive symptoms during or after IFNα treatment. Because patients had lowered tryptophan blood levels and did not response to antidepressants, they received tryptophan up to a dosage of 1,000 mg/day as mono- or add-on treatment. Tryptophan, used as augmentation or monotherapeutic treatment, led to a significant improvement of depressive symptoms in all three patients. A tryptophan deficit seems to be involved in the pathophysiology of persistent mood changes during and after IFNα treatment." @default.
• W2055131488 created "2016-06-24" @default.
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• W2055131488 date "2008-09-01" @default.
• W2055131488 modified "2023-10-02" @default.
• W2055131488 title "Three Cases of Successful Tryptophan Add-On or Monotherapy of Hepatitis C and IFNα-Associated Mood Disorders" @default.
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• W2055131488 doi "https://doi.org/10.1176/appi.psy.49.5.442" @default.
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