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• W2055137002 abstract "Background & Aims: Cyclooxygenase enzymes (COX) generate intermediates in the prostaglandin (PG) cascade. COX-1 is constitutively expressed in many cells, and COX-2 is typically thought to be an inducible isoform. Methods: We evaluated constitutive expression and function of COX-2 in murine gastric muscles. Results: Immunohistochemistry showed COX-2–like immunoreactivity (COX-2–LI) in myenteric neurons. Half the neurons with COX-2–LI expressed nitric oxide synthase (NOS). COX-2–LI was not observed in smooth muscle cells. Interstitial cells of Cajal within muscle layers (IC-IM) expressed COX-2–LI, suggesting a novel role for IC-IM. Molecular studies verified expression of COX-2 in gastric muscles. Quantitative polymerase chain reaction (PCR) showed equal expression of COX-1 and COX-2 in the antrum. COX-2 was more abundant in fundus. Indomethacin and GR253035X, a COX-2 inhibitor, increased antral phasic contractions and potentiated responses to ACh. Indomethacin, but not GR253035X, increased contractions and potentiated responses in tissues of COX-2 knockout mice. Indomethacin and GR253035X reduced tone in the fundus. Conclusions: COX-2 is constitutively expressed by IC-IM and neurons in the stomach and at levels similar to COX-1. Prostanoids produced by COX-2 regulate mechanical activities of fundus and antral muscles.GASTROENTEROLOGY 2002;122:1442-1454" @default.
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• W2055137002 date "2002-05-01" @default.
• W2055137002 modified "2023-09-23" @default.
• W2055137002 title "Constitutive expression and function of cyclooxygenase-2 in murine gastric muscles" @default.
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• W2055137002 doi "https://doi.org/10.1053/gast.2002.33065" @default.
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