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- W2055140868 abstract "Monoclonal antibody 26 (MAb 26) raised against tetanus toxoid has documented cross-reactivity with β2-glycoprotein I. Passive introduction of this antibody in mice results in an antiphospholipid syndrome-like condition. We investigated the effects of MAb 26 on first trimester human trophoblast in vitro.Binding of MAb 26 to placental tissue trophoblast, isolated cytotrophoblast and HTR-8/SVneo cells was analyzed by immunohisto(cyto)chemistry. Possible effects on cell invasion in vitro were assessed by Matrigel assay. Effects on cell viability were assessed by MTT test. A possibility that MAb 26 induces change in levels of effector molecules important for cell invasion was investigated. Integrin subunits α1, α5 and β1, and galectin-1, were analyzed by qPCR and Western blot. Metalloproteinases -2 and -9 were assessed by gelatin zymography.Immunohisto(cyto)chemistry showed binding of MAb 26 to placental tissue trophoblast, isolated cytotrophoblast and HTR-8/SVneo cells. The antibody had a significant inhibitory effect on cell invasion by both isolated cytotrophoblast and HTR-8/SVneo. The antibody induced significant decrease in protein levels of metalloproteinases, integrin subunit α1 and galectin-1. Cell viability was not affected.MAb 26 reduces trophoblast invasion in vitro through decreased levels of metalloproteinases-2 and -9, integrin α1 and galectin-1." @default.
- W2055140868 created "2016-06-24" @default.
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- W2055140868 date "2013-11-01" @default.
- W2055140868 modified "2023-10-12" @default.
- W2055140868 title "Monoclonal antibody 26 cross-reactive with β2-glycoprotein I affects human trophoblast invasion in vitro" @default.
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- W2055140868 doi "https://doi.org/10.1016/j.ejogrb.2013.08.005" @default.
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