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• W2055141523 abstract "Glomerular filtration rate (GFR) can accurately be determined using ⁵¹Cr-ethylenediaminetetraacetic acid (EDTA) plasma clearance counting but is time-consuming and requires technical skills and equipment not always available in imaging departments. ⁶⁸Ga-EDTA can be readily available using an onsite generator, and PET/CT enables both imaging of renal function and accurate camera-based quantitation of clearance of activity from blood and its appearance in the urine. This study aimed to assess agreement between ⁶⁸Ga-EDTA GFR (⁶⁸Ga-GFR) and ⁵¹Cr-EDTA GFR (⁵¹Cr-GFR), using serial plasma sampling and PET imaging. <b>Methods:</b>⁶⁸Ga-EDTA and ⁵¹Cr-EDTA were injected concurrently in 31 patients. Dynamic PET/CT encompassing the kidneys was acquired for 10 min followed by 3 sequential 3-min multibed step acquisitions from kidneys to bladder. PET quantification was performed using renal activity at 1–2 min (PET_initial), renal excretion at 2–10 min (PET_early), and, subsequently, urinary excretion into the collecting system and bladder (PET_late). Plasma sampling at 2, 3, and 4 h was performed, with ⁶⁸Ga followed by ⁵¹Cr counting after positron decay. The level of agreement for GFR determination was calculated using a Bland–Altman plot and Pearson correlation coefficient (PCC). <b>Results:</b>⁵¹Cr-GFR ranged from 10 to 220 mL/min (mean, 85 mL/min). There was good agreement between ⁶⁸Ga-GFR and ⁵¹Cr-GFR using serial plasma sampling, with a Bland–Altman bias of −14 ± 20 mL/min and a PCC of 0.94 (95% confidence interval, 0.88–0.97). Of the 3 methods used for camera-based quantification, the strongest correlation was for plasma sampling–derived GFR with PET_late (PCC of 0.90; 95% confidence interval, 0.80–0.95). <b>Conclusion:</b>⁶⁸Ga-GFR agreed well with ⁵¹Cr-GFR for estimation of GFR using serial plasma counting. PET dynamic imaging provides a method to estimate GFR without plasma sampling, with the additional advantage of enabling renal imaging in a single study. Additional validation in a larger cohort is warranted to further assess utility." @default.
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• W2055141523 date "2015-02-12" @default.
• W2055141523 modified "2023-10-01" @default.
• W2055141523 title "⁶⁸Ga-EDTA PET/CT Imaging and Plasma Clearance for Glomerular Filtration Rate Quantification: Comparison to Conventional ⁵¹Cr-EDTA" @default.
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• W2055141523 doi "https://doi.org/10.2967/jnumed.114.147843" @default.
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