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- W2055143478 abstract "The dual role of nitric oxide in cancer biology is discussed here through the perspective of our work on nitric oxide-mediated signaling events. The nitric oxide-stimulated Src-FAK and Ras-ERK1/2 mitogen-activated protein kinases (MAPKs) oncogenic signaling pathways are discussed, highlighting the cross-talk between 2 major posttrans- lational modifications: protein phosphorylation and protein S-nitrosylation. In addition, we discuss the importance of nitric oxide synthases in cancer biology, focusing on the roles of endothelial nitric oxide synthase and arginase 2 in human thyroid tumor progression. A direct relationship between the expression levels of both enzymes was found in human follicular thyroid carcinoma. Finally, the antioncogenic, proapoptotic actions of nitric oxide based on its anti- adhesive properties are presented and discussed." @default.
- W2055143478 created "2016-06-24" @default.
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- W2055143478 date "2012-01-01" @default.
- W2055143478 modified "2023-10-01" @default.
- W2055143478 title "A Role for Nitric Oxide and for Nitric Oxide Synthases in Tumor Biology" @default.
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- W2055143478 doi "https://doi.org/10.1615/forumimmundisther.2012006134" @default.
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