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- W2055143501 abstract "1. The effect of glutamate analogues was investigated on three identifiable cells in the sub-oesophageal ganglia of the common garden snail, Helix aspersa. 2. The three cells gave different responses to glutamate. Cell E4 gave a biphasic response—hyperpolarization (H response) followed by a depolarization (D response); cell F30 was depolarized whereas cell F1 gave only a hyperpolarization. 3. The equipotent molar ratios (epmrs) of a range of glutamate analogues, as compared with glutamate, were calculated. 4. D-Glutamate was found to be eight to ten times less potent than L-glutamate on all three cells whereas DL-glutamate was equipotent with L-glutamate. 5. Substitution on the α or β carbon of glutamate reduced the activity more than did substitution on the γ carbon. 6. In general, the receptor sites were able to accommodate an increase or reduction of one carbon in the glutamate carbon chain without too severely affecting the glutamate activity. 7. The results support the hypothesis that the glutamate receptors require three ionically charged moieties. The evidence also suggests there are two different receptors: an excitatory receptor with the preferred glutamate conformation folded to resemble L-aspartic acid and an inhibitory receptor for which the preferred model for glutamate activity resembles the rigid structure of Ibotenic acid." @default.
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- W2055143501 date "1975-06-01" @default.
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- W2055143501 title "Structure-activity studies on glutamate receptor sites of three identifiable neurones in the sub-oesophageal ganglia of Helix aspersa" @default.
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- W2055143501 doi "https://doi.org/10.1016/0306-4492(75)90044-1" @default.
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