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• W2055144059 endingPage "4312" @default.
• W2055144059 startingPage "4309" @default.
• W2055144059 abstract "Nerve growth cones isolated from fetal rat brain are highly enriched in a 97-kDa glycoprotein, termed beta gc, that comigrates with the beta subunit of the IGF-I receptor upon two-dimensional PAGE and is disulfide-linked to this receptor's alpha subunit. Antibodies prepared to a conserved domain shared by the insulin and IGF-I receptor beta subunits (AbP2) or to beta gc were used to study receptor distribution further. Subcellular fractionation of the fetal brain segregated most AbP2 immunoreactivity away from growth cones, whereas most beta gc immunoreactivity copurified with growth cones. Experiments involving ligand-activated receptor autophosphorylation confirmed the concentration of IGF-I but not of insulin receptors in growth cone fractions. These results indicate the enrichment of IGF-I receptors in (presumably axonal) growth cones of the differentiating neuron. Furthermore, the segregation of beta gc from AbP2 immunoreactivity suggests that such neurons express an immunochemically distinct variant of the IGF-I receptor beta subunit at the growth cone." @default.
• W2055144059 created "2016-06-24" @default.
• W2055144059 creator A5031952528 @default.
• W2055144059 creator A5066894856 @default.
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• W2055144059 date "1995-05-09" @default.
• W2055144059 modified "2023-10-09" @default.
• W2055144059 title "Insulin-like growth factor I receptors of fetal brain are enriched in nerve growth cones and contain a beta-subunit variant." @default.
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• W2055144059 doi "https://doi.org/10.1073/pnas.92.10.4309" @default.
• W2055144059 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/41933" @default.
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• W2055144059 hasPublicationYear "1995" @default.
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