Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055144221> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2055144221 endingPage "765" @default.
- W2055144221 startingPage "759" @default.
- W2055144221 abstract "Background — Therapeutic angiogenesis is a new approach to treating ischemic heart disease, and the optimal method for assessing its efficacy is unclear. We used myocardial contrast echocardiography (MCE) to evaluate the therapeutic response to the angiogenic agent, vascular endothelial growth factor-121 (VEGF 121 ). Methods and Results — After placement of an ameroid constrictor (day 0) around the left anterior descending artery (LAD), dogs were given intracoronary VEGF 121 protein (108 μg, n=6) or placebo (n=6) on days 7 and 21, and subcutaneous VEGF 121 (1 mg) or placebo on days 8 to 20 and 22 to 27. On day 48, MCE was performed during rest and dobutamine stress. Videointensity ( y ) and pulsing interval ( t ) were fit to an exponential model ( y = A [1− e −βt ]) used to derive indices of red cell velocity (β) and capillary area ( A ), and parameters were compared with radiolabeled microsphere flow data. VEGF 121 treatment resulted in higher resting left anterior descending artery/left circumflex flow ratio compared with placebo ( P <0.03) and improved collateral flow reserve. β was 0.94±0.37 in VEGF 121 dogs versus 0.38±0.31 in controls ( P <0.02), with the greatest difference in the endocardium. The parameter A was comparable in both groups, suggesting that microvascular changes did not alter capillary cross-sectional area, and histology indicated a trend toward higher arteriolar density in VEGF 121 -treated animals. Conclusions — VEGF 121 protein improves collateral flow and reserve. MCE can evaluate the transmural location and structural and functional responses of the microvasculature to angiogenic interventions." @default.
- W2055144221 created "2016-06-24" @default.
- W2055144221 creator A5005790287 @default.
- W2055144221 creator A5027357893 @default.
- W2055144221 creator A5035924029 @default.
- W2055144221 creator A5039045480 @default.
- W2055144221 creator A5039303331 @default.
- W2055144221 creator A5050261399 @default.
- W2055144221 creator A5062420667 @default.
- W2055144221 creator A5065816810 @default.
- W2055144221 creator A5081571713 @default.
- W2055144221 date "2002-02-12" @default.
- W2055144221 modified "2023-09-25" @default.
- W2055144221 title "Myocardial Contrast Echocardiography Can Be Used to Assess the Microvascular Response to Vascular Endothelial Growth Factor-121" @default.
- W2055144221 cites W1985712533 @default.
- W2055144221 cites W1988358708 @default.
- W2055144221 cites W2008591914 @default.
- W2055144221 cites W2023724259 @default.
- W2055144221 cites W2034757554 @default.
- W2055144221 cites W2077323415 @default.
- W2055144221 cites W2112481821 @default.
- W2055144221 cites W2162249561 @default.
- W2055144221 cites W2166350142 @default.
- W2055144221 cites W2264604898 @default.
- W2055144221 doi "https://doi.org/10.1161/hc0602.103634" @default.
- W2055144221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11839634" @default.
- W2055144221 hasPublicationYear "2002" @default.
- W2055144221 type Work @default.
- W2055144221 sameAs 2055144221 @default.
- W2055144221 citedByCount "33" @default.
- W2055144221 countsByYear W20551442212014 @default.
- W2055144221 countsByYear W20551442212016 @default.
- W2055144221 crossrefType "journal-article" @default.
- W2055144221 hasAuthorship W2055144221A5005790287 @default.
- W2055144221 hasAuthorship W2055144221A5027357893 @default.
- W2055144221 hasAuthorship W2055144221A5035924029 @default.
- W2055144221 hasAuthorship W2055144221A5039045480 @default.
- W2055144221 hasAuthorship W2055144221A5039303331 @default.
- W2055144221 hasAuthorship W2055144221A5050261399 @default.
- W2055144221 hasAuthorship W2055144221A5062420667 @default.
- W2055144221 hasAuthorship W2055144221A5065816810 @default.
- W2055144221 hasAuthorship W2055144221A5081571713 @default.
- W2055144221 hasBestOaLocation W20551442211 @default.
- W2055144221 hasConcept C126322002 @default.
- W2055144221 hasConcept C164705383 @default.
- W2055144221 hasConcept C167734588 @default.
- W2055144221 hasConcept C178853913 @default.
- W2055144221 hasConcept C197321550 @default.
- W2055144221 hasConcept C2776820930 @default.
- W2055144221 hasConcept C2777025900 @default.
- W2055144221 hasConcept C2780394083 @default.
- W2055144221 hasConcept C2781185063 @default.
- W2055144221 hasConcept C71924100 @default.
- W2055144221 hasConcept C85378888 @default.
- W2055144221 hasConceptScore W2055144221C126322002 @default.
- W2055144221 hasConceptScore W2055144221C164705383 @default.
- W2055144221 hasConceptScore W2055144221C167734588 @default.
- W2055144221 hasConceptScore W2055144221C178853913 @default.
- W2055144221 hasConceptScore W2055144221C197321550 @default.
- W2055144221 hasConceptScore W2055144221C2776820930 @default.
- W2055144221 hasConceptScore W2055144221C2777025900 @default.
- W2055144221 hasConceptScore W2055144221C2780394083 @default.
- W2055144221 hasConceptScore W2055144221C2781185063 @default.
- W2055144221 hasConceptScore W2055144221C71924100 @default.
- W2055144221 hasConceptScore W2055144221C85378888 @default.
- W2055144221 hasIssue "6" @default.
- W2055144221 hasLocation W20551442211 @default.
- W2055144221 hasLocation W20551442212 @default.
- W2055144221 hasOpenAccess W2055144221 @default.
- W2055144221 hasPrimaryLocation W20551442211 @default.
- W2055144221 hasRelatedWork W1974306297 @default.
- W2055144221 hasRelatedWork W2018734032 @default.
- W2055144221 hasRelatedWork W2055144221 @default.
- W2055144221 hasRelatedWork W2083138758 @default.
- W2055144221 hasRelatedWork W2090198556 @default.
- W2055144221 hasRelatedWork W2114729000 @default.
- W2055144221 hasRelatedWork W2761752797 @default.
- W2055144221 hasRelatedWork W2904337295 @default.
- W2055144221 hasRelatedWork W3014711590 @default.
- W2055144221 hasRelatedWork W3195919262 @default.
- W2055144221 hasVolume "105" @default.
- W2055144221 isParatext "false" @default.
- W2055144221 isRetracted "false" @default.
- W2055144221 magId "2055144221" @default.
- W2055144221 workType "article" @default.