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• W2055144429 startingPage "631" @default.
• W2055144429 abstract "Recent evidence indicates that adaptive T cell-mediated immune responses can regulate innate lymphocytes (natural killer cells and innate lymphoid cells) in an interleukin-2-dependent manner. The authors propose a model in which adaptive T cells function as peripheral antigen-specific sensors that recruit and activate innate lymphocytes to amplify and coordinate local immune responses. Innate lymphocytes — including natural killer cells and the recently discovered innate lymphoid cells — have crucial roles during infection, tissue injury and inflammation. Innate signals regulate the activation and homeostasis of innate lymphocytes. The contribution of the adaptive immune system to the coordination of innate lymphocyte responses is less well understood. In this Opinion article, we review our current understanding of the interactions between adaptive and innate lymphocytes, and propose a model in which T cells of the adaptive immune system function as antigen-specific sensors for the activation of innate lymphocytes to amplify and instruct local immune responses. We highlight the potential roles of regulatory and helper T cells in these processes, and discuss major questions in the emerging area of crosstalk between adaptive and innate lymphocytes." @default.
• W2055144429 created "2016-06-24" @default.
• W2055144429 creator A5011718692 @default.
• W2055144429 creator A5030125111 @default.
• W2055144429 date "2014-08-18" @default.
• W2055144429 modified "2023-10-17" @default.
• W2055144429 title "Interactions between innate and adaptive lymphocytes" @default.
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• W2055144429 doi "https://doi.org/10.1038/nri3726" @default.
• W2055144429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4504695" @default.
• W2055144429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25132095" @default.

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