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- W2055144501 abstract "There is experimental evidence indicating that the non-competitive NMDA receptor antagonist MK-801 impairs cognition and produces a series of schizophrenia-like symptoms in rodents (hypermotility, stereotypies, and ataxia). The present study was designed to investigate the efficacy of the nitric oxide (NO) donor molsidomine in counteracting these MK-801-induced behavioral effects in the rat. In a first study, post-training administration of molsidomine (at 4 but not 2 mg/kg) successfully antagonized MK-801-induced performance deficits in a recognition memory test. In a subsequent study, molsidomine (2 and 4 mg/kg) was shown to be unable to reverse MK-801-induced hypermotility but attenuated stereotypies (continuous movement whole cage, body sway, and head weaving) produced by MK-801. Moreover, at 4 mg/kg this NO donor counteracted MK-801-induced ataxia. Our findings indicate that molsidomine attenuates behavioral effects related to the hypofunction of the NMDA receptor suggesting that NO might be involved in the psychotomimetic effects of non-competitive NMDA receptor antagonists. © 2006 Wiley-Liss, Inc." @default.
- W2055144501 created "2016-06-24" @default.
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- W2055144501 date "2006-01-01" @default.
- W2055144501 modified "2023-10-12" @default.
- W2055144501 title "Nitric oxide donor molsidomine attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801" @default.
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- W2055144501 doi "https://doi.org/10.1002/jnr.20889" @default.
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