FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055146026> ?p ?o ?g. }

• W2055146026 endingPage "263" @default.
• W2055146026 startingPage "252" @default.
• W2055146026 abstract "Objective: The purpose of this study was to determine whether treatment with the immune modulators dexamethasone or interleukin-10 prevents interleukin-1β-induced uterine contractions in a nonhuman primate model. Study Design: Thirteen chronically instrumented rhesus monkeys at 135 ± 1 days of gestation (term, 167 days) received one of three interventions: (1) intra-amniotic interleukin-1β (10 μg) infusion with maternal dexamethasone (1 mg/kg) intravenously every 6 hours for 1 day before interleukin-1β and for 2 days thereafter (n = 4), (2) intra-amniotic interleukin-1β infusion with maternal interleukin-10 (25 μg/kg) given intravenously and 100 μg interleukin-10 given intra-amniotically before the interleukin-1β and continued every 8 hours for 3 days (n = 5), and (3) intra-amniotic interleukin-1β administered alone (n = 5). Uterine activity was monitored continuously and quantified as the hourly contraction area (millimeters of mercury times seconds per hour) in all groups until delivery. Amniotic fluid was sampled for leukocyte counts and assayed for prostaglandins E2 and F2α, cytokines interleukin-1β, interleukin-6, interleukin-8, tumor necrosis factor-α, interleukin-10, and interleukin-1 receptor antagonist by specific assays. Maternal and fetal blood were assayed for cortisol, dehydroepiandrosterone sulfate, and estradiol. Results: Interleukin-1β infusion in the absence of immune modulators resulted in an increase in uterine activity and amniotic fluid proinflammatory cytokines, prostaglandins, and leukocytes. Dexamethasone and interleukin-10 treatment significantly reduced interleukin-1β-induced uterine contractility (P < .05) and amniotic fluid prostaglandins (P < .05) but not interleukin-8 or interleukin-1 receptor antagonist. Amniotic fluid interleukin-6 and maternal and fetal cortisol, dehydroepiandrosterone sulfate, and estradiol concentrations were reduced by dexamethasone (P < .05), whereas tumor necrosis factor-α levels and leukocyte counts were attenuated by interleukin-10 treatment (P < .05). An inverse relationship was noted between amniotic fluid interleukin-10 concentrations and interleukin-1β-induced uterine activity (r = −0.74, P < .05). Conclusion: Dexamethasone and interleukin-10 exert similar inhibitory effects on interleukin-1β-induced uterine activity, which appears to be mediated by a decrease in prostaglandin production. Reduced estrogen biosynthesis or suppression of tumor necrosis factor-α and leukocyte migration may contribute to the tocolytic actions of dexamethasone and interleukin-10, respectively. Dexamethasone and interleukin-10 are likely to be useful adjuncts in the treatment of preterm labor that is associated with inflammation or infection.Am J Obstet Gynecol 2003;188:252-63." @default.
• W2055146026 created "2016-06-24" @default.
• W2055146026 creator A5032311936 @default.
• W2055146026 creator A5055303165 @default.
• W2055146026 creator A5055608441 @default.
• W2055146026 creator A5086443525 @default.
• W2055146026 date "2003-01-01" @default.
• W2055146026 modified "2023-10-16" @default.
• W2055146026 title "Dexamethasone or interleukin-10 blocks interleukin-1β-induced uterine contractions in pregnant rhesus monkeys" @default.
• W2055146026 cites W1522773084 @default.
• W2055146026 cites W1609491606 @default.
• W2055146026 cites W1933480820 @default.
• W2055146026 cites W1968285353 @default.
• W2055146026 cites W1969337504 @default.
• W2055146026 cites W1976542825 @default.
• W2055146026 cites W1978300791 @default.
• W2055146026 cites W1978644867 @default.
• W2055146026 cites W1982049230 @default.
• W2055146026 cites W1983707235 @default.
• W2055146026 cites W1984969043 @default.
• W2055146026 cites W1987425190 @default.
• W2055146026 cites W1988868295 @default.
• W2055146026 cites W1994283810 @default.
• W2055146026 cites W2004011257 @default.
• W2055146026 cites W2006051384 @default.
• W2055146026 cites W2010625294 @default.
• W2055146026 cites W2012194278 @default.
• W2055146026 cites W2021347108 @default.
• W2055146026 cites W2026596500 @default.
• W2055146026 cites W2030033188 @default.
• W2055146026 cites W2054692306 @default.
• W2055146026 cites W2055991864 @default.
• W2055146026 cites W2063259891 @default.
• W2055146026 cites W2064015722 @default.
• W2055146026 cites W2072481942 @default.
• W2055146026 cites W2075459038 @default.
• W2055146026 cites W2083466222 @default.
• W2055146026 cites W2084017217 @default.
• W2055146026 cites W2088206082 @default.
• W2055146026 cites W2091872973 @default.
• W2055146026 cites W2094739664 @default.
• W2055146026 cites W2095772895 @default.
• W2055146026 cites W2097636587 @default.
• W2055146026 cites W2101768385 @default.
• W2055146026 cites W2107105309 @default.
• W2055146026 cites W2110200062 @default.
• W2055146026 cites W2126501787 @default.
• W2055146026 cites W2133584066 @default.
• W2055146026 cites W2145224213 @default.
• W2055146026 cites W2145820173 @default.
• W2055146026 cites W2398624131 @default.
• W2055146026 cites W4232526213 @default.
• W2055146026 cites W4251847787 @default.
• W2055146026 doi "https://doi.org/10.1067/mob.2003.70" @default.
• W2055146026 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12548226" @default.
• W2055146026 hasPublicationYear "2003" @default.
• W2055146026 type Work @default.
• W2055146026 sameAs 2055146026 @default.
• W2055146026 citedByCount "140" @default.
• W2055146026 countsByYear W20551460262012 @default.
• W2055146026 countsByYear W20551460262013 @default.
• W2055146026 countsByYear W20551460262014 @default.
• W2055146026 countsByYear W20551460262015 @default.
• W2055146026 countsByYear W20551460262016 @default.
• W2055146026 countsByYear W20551460262017 @default.
• W2055146026 countsByYear W20551460262018 @default.
• W2055146026 countsByYear W20551460262019 @default.
• W2055146026 countsByYear W20551460262020 @default.
• W2055146026 countsByYear W20551460262021 @default.
• W2055146026 countsByYear W20551460262022 @default.
• W2055146026 countsByYear W20551460262023 @default.
• W2055146026 crossrefType "journal-article" @default.
• W2055146026 hasAuthorship W2055146026A5032311936 @default.
• W2055146026 hasAuthorship W2055146026A5055303165 @default.
• W2055146026 hasAuthorship W2055146026A5055608441 @default.
• W2055146026 hasAuthorship W2055146026A5086443525 @default.
• W2055146026 hasConcept C11988809 @default.
• W2055146026 hasConcept C126322002 @default.
• W2055146026 hasConcept C134018914 @default.
• W2055146026 hasConcept C149892131 @default.
• W2055146026 hasConcept C164027704 @default.
• W2055146026 hasConcept C170493617 @default.
• W2055146026 hasConcept C172680121 @default.
• W2055146026 hasConcept C2776885963 @default.
• W2055146026 hasConcept C2776914184 @default.
• W2055146026 hasConcept C2777371288 @default.
• W2055146026 hasConcept C2778122271 @default.
• W2055146026 hasConcept C2778194526 @default.
• W2055146026 hasConcept C2778690821 @default.
• W2055146026 hasConcept C2779234561 @default.
• W2055146026 hasConcept C2780401358 @default.
• W2055146026 hasConcept C54355233 @default.
• W2055146026 hasConcept C71924100 @default.
• W2055146026 hasConcept C74172505 @default.
• W2055146026 hasConcept C86803240 @default.
• W2055146026 hasConceptScore W2055146026C11988809 @default.
• W2055146026 hasConceptScore W2055146026C126322002 @default.
• W2055146026 hasConceptScore W2055146026C134018914 @default.

• next