FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055149957> ?p ?o ?g. }

• W2055149957 abstract "The homeodomain transcription factor orthopedia (Otp) is an evolutionarily conserved regulator of neuronal fates. In vertebrates, Otp is necessary for the proper development of different regions of the brain and is required in the diencephalon to specify several hypothalamic cell types, including the cells that control the stress response. To understand how this widely expressed transcription factor accomplishes hypothalamus-specific functions, we performed a comprehensive screening of otp cis-regulatory regions in zebrafish.Here, we report the identification of an evolutionarily conserved vertebrate enhancer module with activity in a restricted area of the forebrain, which includes the region of the hypothalamus that controls the stress response. This region includes neurosecretory cells producing Corticotropin-releasing hormone (Crh), Oxytocin (Oxt) and Arginine vasopressin (Avp), which are key components of the stress axis. Lastly, expression of the bacterial nitroreductase gene under this specific enhancer allowed pharmacological attenuation of the stress response in zebrafish larvae.Vertebrates share many cellular and molecular components of the stress response and our work identified a striking conservation at the cis-regulatory level of a key hypothalamic developmental gene. In addition, this enhancer provides a useful tool to manipulate and visualize stress-regulatory hypothalamic cells in vivo with the long-term goal of understanding the ontogeny of the stress axis in vertebrates." @default.
• W2055149957 created "2016-06-24" @default.
• W2055149957 creator A5038423617 @default.
• W2055149957 creator A5040016113 @default.
• W2055149957 creator A5063900559 @default.
• W2055149957 creator A5071241536 @default.
• W2055149957 creator A5084628978 @default.
• W2055149957 date "2014-11-27" @default.
• W2055149957 modified "2023-10-18" @default.
• W2055149957 title "A vertebrate-conserved cis-regulatory module for targeted expression in the main hypothalamic regulatory region for the stress response" @default.
• W2055149957 cites W1549042316 @default.
• W2055149957 cites W1966006200 @default.
• W2055149957 cites W1970231625 @default.
• W2055149957 cites W1977780909 @default.
• W2055149957 cites W1982314306 @default.
• W2055149957 cites W1983109395 @default.
• W2055149957 cites W1984191157 @default.
• W2055149957 cites W1987691900 @default.
• W2055149957 cites W1989062378 @default.
• W2055149957 cites W1998745514 @default.
• W2055149957 cites W2006704109 @default.
• W2055149957 cites W2008208329 @default.
• W2055149957 cites W2008411490 @default.
• W2055149957 cites W2020444846 @default.
• W2055149957 cites W2023261615 @default.
• W2055149957 cites W2023521447 @default.
• W2055149957 cites W2025729362 @default.
• W2055149957 cites W2026503542 @default.
• W2055149957 cites W2030480841 @default.
• W2055149957 cites W2030816023 @default.
• W2055149957 cites W2039213436 @default.
• W2055149957 cites W2040529715 @default.
• W2055149957 cites W2040876899 @default.
• W2055149957 cites W2045295821 @default.
• W2055149957 cites W2045362835 @default.
• W2055149957 cites W2046354569 @default.
• W2055149957 cites W2052590262 @default.
• W2055149957 cites W2055043387 @default.
• W2055149957 cites W2055593778 @default.
• W2055149957 cites W2055649671 @default.
• W2055149957 cites W2057652201 @default.
• W2055149957 cites W2061041720 @default.
• W2055149957 cites W2063807032 @default.
• W2055149957 cites W2064547533 @default.
• W2055149957 cites W2069290560 @default.
• W2055149957 cites W2072718843 @default.
• W2055149957 cites W2074791476 @default.
• W2055149957 cites W2090015201 @default.
• W2055149957 cites W2090025305 @default.
• W2055149957 cites W2092223956 @default.
• W2055149957 cites W2094534764 @default.
• W2055149957 cites W2104809172 @default.
• W2055149957 cites W2105232945 @default.
• W2055149957 cites W2106580666 @default.
• W2055149957 cites W2107533108 @default.
• W2055149957 cites W2116251070 @default.
• W2055149957 cites W2118910836 @default.
• W2055149957 cites W2135245267 @default.
• W2055149957 cites W2136061619 @default.
• W2055149957 cites W2141166900 @default.
• W2055149957 cites W2145334570 @default.
• W2055149957 cites W2166291320 @default.
• W2055149957 cites W2171193618 @default.
• W2055149957 cites W2171512984 @default.
• W2055149957 cites W26482486 @default.
• W2055149957 cites W4210767115 @default.
• W2055149957 cites W4231136836 @default.
• W2055149957 cites W4376044067 @default.
• W2055149957 doi "https://doi.org/10.1186/s12861-014-0041-x" @default.
• W2055149957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4248439" @default.
• W2055149957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25427861" @default.
• W2055149957 hasPublicationYear "2014" @default.
• W2055149957 type Work @default.
• W2055149957 sameAs 2055149957 @default.
• W2055149957 citedByCount "12" @default.
• W2055149957 countsByYear W20551499572015 @default.
• W2055149957 countsByYear W20551499572016 @default.
• W2055149957 countsByYear W20551499572017 @default.
• W2055149957 countsByYear W20551499572018 @default.
• W2055149957 countsByYear W20551499572019 @default.
• W2055149957 countsByYear W20551499572023 @default.
• W2055149957 crossrefType "journal-article" @default.
• W2055149957 hasAuthorship W2055149957A5038423617 @default.
• W2055149957 hasAuthorship W2055149957A5040016113 @default.
• W2055149957 hasAuthorship W2055149957A5063900559 @default.
• W2055149957 hasAuthorship W2055149957A5071241536 @default.
• W2055149957 hasAuthorship W2055149957A5084628978 @default.
• W2055149957 hasBestOaLocation W20551499571 @default.
• W2055149957 hasConcept C104317684 @default.
• W2055149957 hasConcept C111936080 @default.
• W2055149957 hasConcept C121587040 @default.
• W2055149957 hasConcept C165864922 @default.
• W2055149957 hasConcept C169760540 @default.
• W2055149957 hasConcept C21592294 @default.
• W2055149957 hasConcept C2776370428 @default.
• W2055149957 hasConcept C2776878037 @default.
• W2055149957 hasConcept C2778961482 @default.
• W2055149957 hasConcept C2779715522 @default.
• W2055149957 hasConcept C529278444 @default.
• W2055149957 hasConcept C54355233 @default.

• next