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• W2055150750 startingPage "546" @default.
• W2055150750 abstract "The Janus kinases (or Jak kinases) mediate cytokine and growth factor signal transduction. Acquired or inherited Jak mutations can result in dysregulation of Jak-mediated signal transduction and can be critical to disease acquisition in neoplasias including acute myeloid, acute lymphoblastic and acute megakaryoblastic leukemias, and in rare X-linked severe combined immunodeficiency. The discovery of an acquired Jak2 point mutation, V617F, in significant numbers of patients with classical myeloproliferative disorders has increased the interest in development of Jak2-specific tyrosine kinase inhibitors and consequently there are now over 20 publically available structures of Jak kinase domains that describe all four family members, Jak1, Jak2, Jak3, and Tyk2. Here we review the recent advances in understanding the druggable structure and function of the Jak family, with a focus on the structural biology of the Jak kinase domain. We will discuss how these advances impact the development of Jak-targeted therapeutics. Keywords: Jak kinase, crystal structure, CP-690, 550, Jak2-V617F, kinase inhibitor, drug, cytokine signaling, mutation, translocation, STAT" @default.
• W2055150750 created "2016-06-24" @default.
• W2055150750 creator A5024341499 @default.
• W2055150750 creator A5062174303 @default.
• W2055150750 date "2011-04-01" @default.
• W2055150750 modified "2023-09-27" @default.
• W2055150750 title "The Use of Structural Biology in Janus Kinase Targeted Drug Discovery" @default.
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• W2055150750 cites W1509504924 @default.
• W2055150750 cites W1596544970 @default.
• W2055150750 cites W1872952115 @default.
• W2055150750 cites W1964220962 @default.
• W2055150750 cites W1964396270 @default.
• W2055150750 cites W1966924224 @default.
• W2055150750 cites W1968531519 @default.
• W2055150750 cites W1977686680 @default.
• W2055150750 cites W1978227537 @default.
• W2055150750 cites W1980568348 @default.
• W2055150750 cites W1984703212 @default.
• W2055150750 cites W1985944682 @default.
• W2055150750 cites W1987162869 @default.
• W2055150750 cites W1988522068 @default.
• W2055150750 cites W1988588903 @default.
• W2055150750 cites W1990069486 @default.
• W2055150750 cites W1992945955 @default.
• W2055150750 cites W1994105285 @default.
• W2055150750 cites W1994455229 @default.
• W2055150750 cites W1996812850 @default.
• W2055150750 cites W1997785224 @default.
• W2055150750 cites W1998752963 @default.
• W2055150750 cites W2001094827 @default.
• W2055150750 cites W2001519848 @default.
• W2055150750 cites W2001638504 @default.
• W2055150750 cites W2006795381 @default.
• W2055150750 cites W2013178046 @default.
• W2055150750 cites W2016449268 @default.
• W2055150750 cites W2018983791 @default.
• W2055150750 cites W2024873935 @default.
• W2055150750 cites W2025316432 @default.
• W2055150750 cites W2027613124 @default.
• W2055150750 cites W2029275361 @default.
• W2055150750 cites W2031060692 @default.
• W2055150750 cites W2040551905 @default.
• W2055150750 cites W2040756303 @default.
• W2055150750 cites W2042593266 @default.
• W2055150750 cites W2046133002 @default.
• W2055150750 cites W2049145190 @default.
• W2055150750 cites W2055339871 @default.
• W2055150750 cites W2057360098 @default.
• W2055150750 cites W2066614655 @default.
• W2055150750 cites W2068147729 @default.
• W2055150750 cites W2080444865 @default.
• W2055150750 cites W2089330303 @default.
• W2055150750 cites W2096577704 @default.
• W2055150750 cites W2098223746 @default.
• W2055150750 cites W2102709092 @default.
• W2055150750 cites W2104485296 @default.
• W2055150750 cites W2105949419 @default.
• W2055150750 cites W2109224123 @default.
• W2055150750 cites W2110369495 @default.
• W2055150750 cites W2114713566 @default.
• W2055150750 cites W2116878961 @default.
• W2055150750 cites W2117926449 @default.
• W2055150750 cites W2119674879 @default.
• W2055150750 cites W2128307445 @default.
• W2055150750 cites W2130003099 @default.
• W2055150750 cites W2130062751 @default.
• W2055150750 cites W2131174104 @default.
• W2055150750 cites W2132334410 @default.
• W2055150750 cites W2135699328 @default.
• W2055150750 cites W2138165161 @default.
• W2055150750 cites W2140010294 @default.
• W2055150750 cites W2141032550 @default.
• W2055150750 cites W2143141179 @default.
• W2055150750 cites W2144664431 @default.
• W2055150750 cites W2145968395 @default.
• W2055150750 cites W2146150971 @default.
• W2055150750 cites W2146239050 @default.
• W2055150750 cites W2147066734 @default.
• W2055150750 cites W2149952120 @default.
• W2055150750 cites W2152877278 @default.
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• W2055150750 doi "https://doi.org/10.2174/138945011794751528" @default.
• W2055150750 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3786457" @default.
• W2055150750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21126226" @default.
• W2055150750 hasPublicationYear "2011" @default.
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