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• W2055150968 abstract "Purpose: The authors describe 2 cases of orbital xanthogranulomatous disease associated with an increase in IgG4-positive plasma cells, and also examine IgG4 in other types of orbital inflammation.Methods: Immunohistochemistry for total IgG and IgG4 was performed in 18 cases of orbital inflammation, including chronic dacryoadenitis (n = 10), necrobiotic xanthogranuloma (n = 2), xanthogranuloma (n = 1), idiopathic orbital inflammation/pseudotumor (n = 4), and fungal infection (n = 1).Results: One patient presenting with necrobiotic xanthogranuloma had signs of systemic IgG4 disease. His orbital lesion showed an elevated number of IgG4 positive plasma cells (55%). An orbital xanthogranulomatous lesion in a second patient lacking systemic symptoms also contained a high percentage of IgG4-positive plasma cells (80%). Only 1 case of chronic dacryoadenitis contained prominent IgG4-positive plasma cells (mean 17/hpf).Conclusions: IgG4-positive plasma cells are relatively rare in nonsclerosing orbital inflammatory lesions. However, systemic disease IgG4 can be associated with necrobiotic xanthogranuloma of the orbit." @default.
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• W2055150968 date "2010-08-17" @default.
• W2055150968 modified "2023-10-17" @default.
• W2055150968 title "Orbital Necrobiotic Xanthogranuloma Associated With Systemic IgG4 Disease" @default.
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• W2055150968 doi "https://doi.org/10.3109/09273948.2010.490629" @default.
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