Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055165793> ?p ?o ?g. }
- W2055165793 endingPage "997" @default.
- W2055165793 startingPage "988" @default.
- W2055165793 abstract "Muscle-invasive urothelial carcinomas are heterogeneous neoplasms for which the clonal relationship with low-grade urothelial dysplasia and carcinomas in situ remains unknown, and both monoclonal and field change models have been proposed. Low-grade dysplasia (18) and carcinoma in situ (12) associated with muscle-invasive urothelial carcinoma were microdissected and topographically analyzed (intraepithelial and invasive superficial and deep to muscularis mucosa) for methylation pattern of androgen receptor alleles, TP53, RB1, WT1, and NF1 microsatellite analysis to assess clonal identity; MLH1 and MSH2 sequencing/immunostaining. Appropriate controls were run. Carcinoma in situ (100%) and invasive urothelial carcinoma (100%) revealed monoclonal patterns, whereas low-grade dysplasia was preferentially polyclonal (80%). Carcinoma in situ showed aneuploid DNA content and more abnormal microsatellites than the corresponding invasive compartments, opposite to low-grade dysplasia. Absent MLH1 protein expression with no gene mutations were identified in carcinoma in situ and nodular-trabecular urothelial carcinoma with high microsatellite abnormalities. Somatic mismatch repair protein down-regulation and the accumulation of tumor suppressor gene microsatellite abnormalities contribute to a molecular evolution for monoclonal carcinoma in situ divergent from coexistent muscle-invasive urothelial carcinoma. Low-grade dysplasia is however unlikely connected with this molecular progression." @default.
- W2055165793 created "2016-06-24" @default.
- W2055165793 creator A5002835039 @default.
- W2055165793 creator A5017444066 @default.
- W2055165793 creator A5035019912 @default.
- W2055165793 creator A5072872701 @default.
- W2055165793 date "2009-07-01" @default.
- W2055165793 modified "2023-10-18" @default.
- W2055165793 title "Coexistent intraurothelial carcinoma and muscle-invasive urothelial carcinoma of the bladder: clonality and somatic down-regulation of DNA mismatch repair" @default.
- W2055165793 cites W1495813818 @default.
- W2055165793 cites W1535259433 @default.
- W2055165793 cites W161538641 @default.
- W2055165793 cites W177982968 @default.
- W2055165793 cites W1900816255 @default.
- W2055165793 cites W1964045405 @default.
- W2055165793 cites W1965842639 @default.
- W2055165793 cites W1971377958 @default.
- W2055165793 cites W1973867379 @default.
- W2055165793 cites W1975013621 @default.
- W2055165793 cites W1976165287 @default.
- W2055165793 cites W1989901426 @default.
- W2055165793 cites W1992205241 @default.
- W2055165793 cites W1993847461 @default.
- W2055165793 cites W2001589308 @default.
- W2055165793 cites W2007958019 @default.
- W2055165793 cites W2008213398 @default.
- W2055165793 cites W2014461348 @default.
- W2055165793 cites W2016298576 @default.
- W2055165793 cites W2018518227 @default.
- W2055165793 cites W2035326480 @default.
- W2055165793 cites W2061035319 @default.
- W2055165793 cites W2063805596 @default.
- W2055165793 cites W2065831982 @default.
- W2055165793 cites W2068272550 @default.
- W2055165793 cites W2075693179 @default.
- W2055165793 cites W2081129974 @default.
- W2055165793 cites W2087137653 @default.
- W2055165793 cites W2088582178 @default.
- W2055165793 cites W2089999099 @default.
- W2055165793 cites W2091904284 @default.
- W2055165793 cites W2098203177 @default.
- W2055165793 cites W2118067575 @default.
- W2055165793 cites W2131383451 @default.
- W2055165793 cites W2137858459 @default.
- W2055165793 cites W2163465543 @default.
- W2055165793 cites W2167320907 @default.
- W2055165793 cites W2169522098 @default.
- W2055165793 cites W2170806909 @default.
- W2055165793 cites W2260430648 @default.
- W2055165793 cites W2317853404 @default.
- W2055165793 cites W2400320712 @default.
- W2055165793 cites W2411520188 @default.
- W2055165793 cites W3006027602 @default.
- W2055165793 cites W2372936169 @default.
- W2055165793 doi "https://doi.org/10.1016/j.humpath.2008.12.009" @default.
- W2055165793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19368958" @default.
- W2055165793 hasPublicationYear "2009" @default.
- W2055165793 type Work @default.
- W2055165793 sameAs 2055165793 @default.
- W2055165793 citedByCount "10" @default.
- W2055165793 countsByYear W20551657932012 @default.
- W2055165793 countsByYear W20551657932017 @default.
- W2055165793 countsByYear W20551657932018 @default.
- W2055165793 countsByYear W20551657932020 @default.
- W2055165793 crossrefType "journal-article" @default.
- W2055165793 hasAuthorship W2055165793A5002835039 @default.
- W2055165793 hasAuthorship W2055165793A5017444066 @default.
- W2055165793 hasAuthorship W2055165793A5035019912 @default.
- W2055165793 hasAuthorship W2055165793A5072872701 @default.
- W2055165793 hasConcept C121608353 @default.
- W2055165793 hasConcept C142724271 @default.
- W2055165793 hasConcept C2775894508 @default.
- W2055165793 hasConcept C2777546739 @default.
- W2055165793 hasConcept C2777661416 @default.
- W2055165793 hasConcept C2779115348 @default.
- W2055165793 hasConcept C502942594 @default.
- W2055165793 hasConcept C526805850 @default.
- W2055165793 hasConcept C54355233 @default.
- W2055165793 hasConcept C60748783 @default.
- W2055165793 hasConcept C71924100 @default.
- W2055165793 hasConcept C86803240 @default.
- W2055165793 hasConceptScore W2055165793C121608353 @default.
- W2055165793 hasConceptScore W2055165793C142724271 @default.
- W2055165793 hasConceptScore W2055165793C2775894508 @default.
- W2055165793 hasConceptScore W2055165793C2777546739 @default.
- W2055165793 hasConceptScore W2055165793C2777661416 @default.
- W2055165793 hasConceptScore W2055165793C2779115348 @default.
- W2055165793 hasConceptScore W2055165793C502942594 @default.
- W2055165793 hasConceptScore W2055165793C526805850 @default.
- W2055165793 hasConceptScore W2055165793C54355233 @default.
- W2055165793 hasConceptScore W2055165793C60748783 @default.
- W2055165793 hasConceptScore W2055165793C71924100 @default.
- W2055165793 hasConceptScore W2055165793C86803240 @default.
- W2055165793 hasIssue "7" @default.
- W2055165793 hasLocation W20551657931 @default.
- W2055165793 hasLocation W20551657932 @default.
- W2055165793 hasOpenAccess W2055165793 @default.
- W2055165793 hasPrimaryLocation W20551657931 @default.