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- W2055170483 abstract "Abstract As dibenzo-p-dioxin (Dpd) showed a relatively low solubility in olive oil, and consequently, it was difficult to use a small volume to reduce the burden to animals, the toxicity of Dpd was first examined by suspension in distilled water. The maximum dose (5g/kg) for low-toxic substances, was tested here, but no change occurred in the general conditions and growth of the animals except for the death of one female rat and slight decreases in body weights of male and female animals. On the other hand, since completely dissolved Dpd in olive oil was used in the second test, the dose volume per animal became as high 35ml/kg and appeared to be the safety-limit volume for the rodent. Death during the experiment occurred in the mice that received 1,000mg/kg or higher of Dpd and also in the rats that received 1,500mg/kg or higher. In summary the LD value for male mice was estimated by taking the geometrical mean of 1,000mg/kg, which showed a death rate of 100%, and 750mg/kg, which showed a rate of 0%. The LD value for female mice was estimated by Litchfield-Wilcoxon's method using a probability-logarithm scale, and it was calculated to be 1,050mg/kg. The LD value for male rats was calculated to be 1,730mg/kg, and for female rats was found to be 1,220mg/kg." @default.
- W2055170483 created "2016-06-24" @default.
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- W2055170483 date "1989-01-01" @default.
- W2055170483 modified "2023-09-27" @default.
- W2055170483 title "Acute toxicity of dibenzo-p-dioxin in mice and rats" @default.
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- W2055170483 doi "https://doi.org/10.1016/0045-6535(89)90446-3" @default.
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