FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055174648> ?p ?o ?g. }

• W2055174648 endingPage "167" @default.
• W2055174648 startingPage "160" @default.
• W2055174648 abstract "Objectives: To determine the diagnostic and prognostic significance of growth factors and the urokinase-type plasminogen activator (uPA) system in pancreatic ductal adenocarcinoma (PDAC) using a multigene assay. Methods: Messenger RNA (mRNA) expression of 15 genes from epidermal growth factor receptor, insulin-like growth factor (IGF), and uPA families were measured in 46 PDAC tissue samples using quantitative real-time reverse transcription-polymerase chain reaction. These results were compared with those of the uninvolved adjacent (AP) tissue and benign mucinous cystadenomas (BMC). The mRNA expression was evaluated using logistic regression and receiver operating characteristic area under the curve (ROC AUC) analyses. Their relationship with prognosis was tested by Cox regression multivariate analysis. Results: All genes were overexpressed in most of the PDAC tissue. When compared with AP tissue, the median expression values for IGF-binding protein 3 (IGFBP-3) and uPA receptor (uPAR) was 9.8- and 9.6-fold, respectively. Expression levels of uPA, uPAR, IGF-I, and IGFBP-3 mRNA were significantly greater in PDAC than in BMC. The IGFBP-3 mRNA expression demonstrated greatest ROC AUC values for PDAC versus AP tissue (ROC AUC, 0.745; 95% confidence interval [CI], 0.65-0.86); whereas ROC AUC values were greatest for uPAR when PDAC was compared with BMC (ROC AUC, 0.846; 95% CI, 0.76-0.94). The combination of uPA, uPAR, and IGF-I significantly improved discriminatory power (ROC AUC, 0.965; 95% CI, 0.93-1.00). The IGFBP-3, uPA, plasminogen activator inhibitor-2, and International Union Against Cancer stage had a significant influence on survival, but the effect of IGFBP-3 was lost after multivariate stepwise analysis. Conclusions: These results indicate that there is an influence of IGF system in tumor progression from BMC to PDAC, whereas the uPA/uPAR system has the greater influence on survival in PDAC." @default.
• W2055174648 created "2016-06-24" @default.
• W2055174648 creator A5034795863 @default.
• W2055174648 creator A5044901015 @default.
• W2055174648 creator A5059586100 @default.
• W2055174648 creator A5063657901 @default.
• W2055174648 creator A5091144056 @default.
• W2055174648 date "2008-03-01" @default.
• W2055174648 modified "2023-10-17" @default.
• W2055174648 title "Prognostic Significance of Growth Factors and the Urokinase-Type Plasminogen Activator System in Pancreatic Ductal Adenocarcinoma" @default.
• W2055174648 cites W1536554401 @default.
• W2055174648 cites W1570162947 @default.
• W2055174648 cites W164180253 @default.
• W2055174648 cites W1964010757 @default.
• W2055174648 cites W1964170499 @default.
• W2055174648 cites W1973434014 @default.
• W2055174648 cites W1976174965 @default.
• W2055174648 cites W1978591675 @default.
• W2055174648 cites W2008138631 @default.
• W2055174648 cites W2011550114 @default.
• W2055174648 cites W2011816149 @default.
• W2055174648 cites W2015080218 @default.
• W2055174648 cites W2016103788 @default.
• W2055174648 cites W2026314750 @default.
• W2055174648 cites W2028701348 @default.
• W2055174648 cites W2030229250 @default.
• W2055174648 cites W2059972525 @default.
• W2055174648 cites W2070877080 @default.
• W2055174648 cites W2085560833 @default.
• W2055174648 cites W2087583527 @default.
• W2055174648 cites W2096959265 @default.
• W2055174648 cites W2099249565 @default.
• W2055174648 cites W2108244474 @default.
• W2055174648 cites W2116152377 @default.
• W2055174648 cites W2126117802 @default.
• W2055174648 cites W2138178697 @default.
• W2055174648 cites W2148802044 @default.
• W2055174648 cites W2149548143 @default.
• W2055174648 cites W2160077996 @default.
• W2055174648 cites W2160835537 @default.
• W2055174648 cites W2166655074 @default.
• W2055174648 cites W2166770565 @default.
• W2055174648 cites W2328176404 @default.
• W2055174648 cites W4231031590 @default.
• W2055174648 doi "https://doi.org/10.1097/mpa.0b013e31815750f0" @default.
• W2055174648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18376307" @default.
• W2055174648 hasPublicationYear "2008" @default.
• W2055174648 type Work @default.
• W2055174648 sameAs 2055174648 @default.
• W2055174648 citedByCount "51" @default.
• W2055174648 countsByYear W20551746482012 @default.
• W2055174648 countsByYear W20551746482013 @default.
• W2055174648 countsByYear W20551746482014 @default.
• W2055174648 countsByYear W20551746482015 @default.
• W2055174648 countsByYear W20551746482016 @default.
• W2055174648 countsByYear W20551746482017 @default.
• W2055174648 countsByYear W20551746482018 @default.
• W2055174648 countsByYear W20551746482019 @default.
• W2055174648 countsByYear W20551746482020 @default.
• W2055174648 countsByYear W20551746482021 @default.
• W2055174648 countsByYear W20551746482022 @default.
• W2055174648 countsByYear W20551746482023 @default.
• W2055174648 crossrefType "journal-article" @default.
• W2055174648 hasAuthorship W2055174648A5034795863 @default.
• W2055174648 hasAuthorship W2055174648A5044901015 @default.
• W2055174648 hasAuthorship W2055174648A5059586100 @default.
• W2055174648 hasAuthorship W2055174648A5063657901 @default.
• W2055174648 hasAuthorship W2055174648A5091144056 @default.
• W2055174648 hasConcept C121608353 @default.
• W2055174648 hasConcept C126322002 @default.
• W2055174648 hasConcept C143998085 @default.
• W2055174648 hasConcept C2776929539 @default.
• W2055174648 hasConcept C2779679481 @default.
• W2055174648 hasConcept C2780210213 @default.
• W2055174648 hasConcept C2780675426 @default.
• W2055174648 hasConcept C2909373784 @default.
• W2055174648 hasConcept C502942594 @default.
• W2055174648 hasConcept C56219504 @default.
• W2055174648 hasConcept C58471807 @default.
• W2055174648 hasConcept C71924100 @default.
• W2055174648 hasConcept C86803240 @default.
• W2055174648 hasConceptScore W2055174648C121608353 @default.
• W2055174648 hasConceptScore W2055174648C126322002 @default.
• W2055174648 hasConceptScore W2055174648C143998085 @default.
• W2055174648 hasConceptScore W2055174648C2776929539 @default.
• W2055174648 hasConceptScore W2055174648C2779679481 @default.
• W2055174648 hasConceptScore W2055174648C2780210213 @default.
• W2055174648 hasConceptScore W2055174648C2780675426 @default.
• W2055174648 hasConceptScore W2055174648C2909373784 @default.
• W2055174648 hasConceptScore W2055174648C502942594 @default.
• W2055174648 hasConceptScore W2055174648C56219504 @default.
• W2055174648 hasConceptScore W2055174648C58471807 @default.
• W2055174648 hasConceptScore W2055174648C71924100 @default.
• W2055174648 hasConceptScore W2055174648C86803240 @default.
• W2055174648 hasIssue "2" @default.
• W2055174648 hasLocation W20551746481 @default.
• W2055174648 hasLocation W20551746482 @default.
• W2055174648 hasOpenAccess W2055174648 @default.

• next