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- W2055181323 abstract "Toll-like receptors (TLRs) are an ancient family of genes encoding transmembrane proteins that bind pathogen-specific molecules and initiate both innate and adaptive aspects of the immune response. Our goal was to determine whether these genes show sufficient genetic diversity in a bottlenecked population to be a useful addition or alternative to the more commonly employed major histocompatibility complex (MHC) genotyping in a conservation genetics context. We amplified all known avian TLR genes in a severely bottlenecked population of New Zealand's Stewart Island robin (Petroica australis rakiura), for which reduced microsatellite diversity was previously observed. We genotyped 17-24 birds from a reintroduced island population (including the 12 founders) for nine genes, seven of which were polymorphic. We observed a total of 24 single-nucleotide polymorphisms overall, 15 of which were non-synonymous, representing up to five amino-acid variants at a locus. One locus (TLR1LB) showed evidence of past directional selection. Results also confirmed a passerine duplication of TLR7. The levels of TLR diversity that we observe are sufficient to justify their further use in addressing conservation genetic questions, even in bottlenecked populations." @default.
- W2055181323 created "2016-06-24" @default.
- W2055181323 creator A5002354944 @default.
- W2055181323 creator A5008983231 @default.
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- W2055181323 creator A5076143133 @default.
- W2055181323 date "2012-09-14" @default.
- W2055181323 modified "2023-10-06" @default.
- W2055181323 title "Variation at Innate Immunity Toll-Like Receptor Genes in a Bottlenecked Population of a New Zealand Robin" @default.
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- W2055181323 doi "https://doi.org/10.1371/journal.pone.0045011" @default.
- W2055181323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3443209" @default.
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- W2055181323 hasPublicationYear "2012" @default.
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