Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055199871> ?p ?o ?g. }
- W2055199871 endingPage "666" @default.
- W2055199871 startingPage "662" @default.
- W2055199871 abstract "The natural product aigialomycin D (1) is a member of the resorcylic acid lactone (RAL) family possessing protein kinase inhibitory activities. This paper describes the synthesis of aigialomycin D and a series of its analogues and their activity for the inhibition of protein kinases related to cancer pathways. A preliminary study of these compounds in the inhibition of CDK2/cyclin A kinase has found that aigialomycin D and analogues 11 and 23 are moderate CDK2/cyclin A inhibitors with IC50 values of ca. 20 μM. Kinase profiling of aigialomycin D against a panel of kinases has led to the identification of MNK2 as a promising target (IC50 = 0.45 μM), and preliminary structure-activity relationship studies have been carried out to identify the essential functional groups for activity." @default.
- W2055199871 created "2016-06-24" @default.
- W2055199871 creator A5012764458 @default.
- W2055199871 creator A5014129248 @default.
- W2055199871 creator A5029259484 @default.
- W2055199871 creator A5031274551 @default.
- W2055199871 creator A5068378847 @default.
- W2055199871 creator A5079787166 @default.
- W2055199871 date "2011-08-01" @default.
- W2055199871 modified "2023-10-16" @default.
- W2055199871 title "Exploring Aigialomycin D and Its Analogues as Protein Kinase Inhibitors for Cancer Targets" @default.
- W2055199871 cites W1964675052 @default.
- W2055199871 cites W1965909642 @default.
- W2055199871 cites W1966963973 @default.
- W2055199871 cites W1967625949 @default.
- W2055199871 cites W1971438689 @default.
- W2055199871 cites W1977450957 @default.
- W2055199871 cites W1993628564 @default.
- W2055199871 cites W1995038735 @default.
- W2055199871 cites W2000137445 @default.
- W2055199871 cites W2000571234 @default.
- W2055199871 cites W2003445065 @default.
- W2055199871 cites W2003830859 @default.
- W2055199871 cites W2004947855 @default.
- W2055199871 cites W2005111749 @default.
- W2055199871 cites W2009393550 @default.
- W2055199871 cites W2010609706 @default.
- W2055199871 cites W2011826559 @default.
- W2055199871 cites W2015796126 @default.
- W2055199871 cites W2037874673 @default.
- W2055199871 cites W2049886087 @default.
- W2055199871 cites W2052981505 @default.
- W2055199871 cites W2062832479 @default.
- W2055199871 cites W2065613854 @default.
- W2055199871 cites W2066998725 @default.
- W2055199871 cites W2074918415 @default.
- W2055199871 cites W2077804275 @default.
- W2055199871 cites W2082170965 @default.
- W2055199871 cites W2083526450 @default.
- W2055199871 cites W2086141155 @default.
- W2055199871 cites W2087047683 @default.
- W2055199871 cites W2093239060 @default.
- W2055199871 cites W2095750516 @default.
- W2055199871 cites W2100170706 @default.
- W2055199871 cites W2110364290 @default.
- W2055199871 cites W2138778824 @default.
- W2055199871 cites W2139205810 @default.
- W2055199871 cites W2148013004 @default.
- W2055199871 cites W2162367407 @default.
- W2055199871 cites W2324223618 @default.
- W2055199871 cites W2949531320 @default.
- W2055199871 cites W2949616108 @default.
- W2055199871 cites W363037004 @default.
- W2055199871 cites W4255298747 @default.
- W2055199871 doi "https://doi.org/10.1021/ml200067t" @default.
- W2055199871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4018073" @default.
- W2055199871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24900361" @default.
- W2055199871 hasPublicationYear "2011" @default.
- W2055199871 type Work @default.
- W2055199871 sameAs 2055199871 @default.
- W2055199871 citedByCount "25" @default.
- W2055199871 countsByYear W20551998712012 @default.
- W2055199871 countsByYear W20551998712013 @default.
- W2055199871 countsByYear W20551998712014 @default.
- W2055199871 countsByYear W20551998712015 @default.
- W2055199871 countsByYear W20551998712016 @default.
- W2055199871 countsByYear W20551998712017 @default.
- W2055199871 countsByYear W20551998712018 @default.
- W2055199871 countsByYear W20551998712020 @default.
- W2055199871 countsByYear W20551998712021 @default.
- W2055199871 countsByYear W20551998712022 @default.
- W2055199871 crossrefType "journal-article" @default.
- W2055199871 hasAuthorship W2055199871A5012764458 @default.
- W2055199871 hasAuthorship W2055199871A5014129248 @default.
- W2055199871 hasAuthorship W2055199871A5029259484 @default.
- W2055199871 hasAuthorship W2055199871A5031274551 @default.
- W2055199871 hasAuthorship W2055199871A5068378847 @default.
- W2055199871 hasAuthorship W2055199871A5079787166 @default.
- W2055199871 hasBestOaLocation W20551998712 @default.
- W2055199871 hasConcept C124320809 @default.
- W2055199871 hasConcept C1491633281 @default.
- W2055199871 hasConcept C184235292 @default.
- W2055199871 hasConcept C185592680 @default.
- W2055199871 hasConcept C193042331 @default.
- W2055199871 hasConcept C202751555 @default.
- W2055199871 hasConcept C2777752497 @default.
- W2055199871 hasConcept C2779396153 @default.
- W2055199871 hasConcept C29537977 @default.
- W2055199871 hasConcept C51853150 @default.
- W2055199871 hasConcept C55493867 @default.
- W2055199871 hasConcept C70721500 @default.
- W2055199871 hasConcept C82495950 @default.
- W2055199871 hasConcept C86803240 @default.
- W2055199871 hasConcept C97029542 @default.
- W2055199871 hasConceptScore W2055199871C124320809 @default.
- W2055199871 hasConceptScore W2055199871C1491633281 @default.
- W2055199871 hasConceptScore W2055199871C184235292 @default.
- W2055199871 hasConceptScore W2055199871C185592680 @default.