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- W2055210631 abstract "To the Editor. — Clozapine hydrochloride, an atypical antipsychotic drug, has been reported to occupy fewer striatal D 2 dopamine receptors ( DRD2 ) (38% to 63%) than typical neuroleptic drugs (>70%), as determined by positron emission tomography (PET) using raclopride labeled with carbon 11. 1-3 Furthermore, clozapine has been shown by PET studies using 11 CSchering 23390 as ligand to occupy more D 1 dopamine receptors ( DRD1 ) than typical neuroleptics. 2,3 See also p 538. Decreased DRD2 and increased DRD1 occupancy has been suggested as the explanation of why clozapine does not produce extrapyramidal symptoms in humans. 3 We have offered an alternative theory, namely, that clozapine produces fewer extrapyramidal symptoms because of its higher serotonin 2 (5-HT 2 ) receptor-blocking properties compared with its DRD2 -blocking properties. 4 We have also suggested that the latter mechanism is relevant to the antipsychotic advantages of clozapine. 5 Others 5,6 have suggested that the" @default.
- W2055210631 created "2016-06-24" @default.
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- W2055210631 date "1992-07-01" @default.
- W2055210631 modified "2023-09-25" @default.
- W2055210631 title "In Vivo Occupancy of Dopamine Receptors by Antipsychotic Drugs" @default.
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- W2055210631 doi "https://doi.org/10.1001/archpsyc.1992.01820070082019" @default.
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