FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055215877> ?p ?o ?g. }

• W2055215877 endingPage "225" @default.
• W2055215877 startingPage "218" @default.
• W2055215877 abstract "In this study, isothermal titration microcalorimetry (ITC) and molecular modeling were used to investigate the mechanism of formation of supramolecular nanoassemblies prepared by mixing aqueous solutions of two associative polymers (i.e. polymerised beta-CD (p beta-CD) and dextran grafted with lauryl side chains (MD)). Their capacity to entrap a contrast agent for magnetic resonance imaging (a gadolinium (Gd(3+)) derivative) has been determined by the same methods. ITC experiments have been employed to evaluate the stoichiometry of interaction (N), association constants (K) and thermodynamic parameter variation associated with complexation between hosts and guests involved in this system. The inclusion compounds studied were: as hosts, beta-CD and p beta-CD, and as guests, MD, adamantyl amine, and a Gd(3+) complex functionalized with adamantane. It has been demonstrated that p beta-CD cavities tend to interact more favourably with MD (K=25,000 M(-1)) than with adamantyl amine (K=3650 M(-1)) and Gd(3+) complex (K=1460 M(-1)), forming 1:1 complexes, as also confirmed by molecular modeling. Noteworthy, the Gd(3+) derivatives, although incorporated in the supramolecular nanoassemblies (by inclusion into the beta-CD cavities of p beta-CD), did not destabilize the p beta-CD-MD inclusion complexes, probably because the interaction between p beta-CD and MD was stronger. Finally, the analysis of thermodynamic parameters revealed that the interaction between MD and p beta-CD was entropy driven (|Delta H|<|T Delta S|) while the interactions of adamantyl amine and Gd(3+) complex with beta-CD and p beta-CD were enthalpy driven and dominated by van der Walls forces (|Delta H|>|T Delta S|)." @default.
• W2055215877 created "2016-06-24" @default.
• W2055215877 creator A5003885398 @default.
• W2055215877 creator A5015064590 @default.
• W2055215877 creator A5028415813 @default.
• W2055215877 creator A5078174247 @default.
• W2055215877 date "2009-09-01" @default.
• W2055215877 modified "2023-09-25" @default.
• W2055215877 title "Microcalorimetric investigation on the formation of supramolecular nanoassemblies of associative polymers loaded with gadolinium chelate derivatives" @default.
• W2055215877 cites W1963829018 @default.
• W2055215877 cites W1977984095 @default.
• W2055215877 cites W1983497025 @default.
• W2055215877 cites W1983588689 @default.
• W2055215877 cites W1989949962 @default.
• W2055215877 cites W1990194219 @default.
• W2055215877 cites W1992966291 @default.
• W2055215877 cites W2002096443 @default.
• W2055215877 cites W2003047669 @default.
• W2055215877 cites W2014503864 @default.
• W2055215877 cites W2025458503 @default.
• W2055215877 cites W2026912725 @default.
• W2055215877 cites W2028914600 @default.
• W2055215877 cites W2030462177 @default.
• W2055215877 cites W2030697678 @default.
• W2055215877 cites W2031964870 @default.
• W2055215877 cites W2033503179 @default.
• W2055215877 cites W2039104539 @default.
• W2055215877 cites W2041771820 @default.
• W2055215877 cites W2042177461 @default.
• W2055215877 cites W2045928772 @default.
• W2055215877 cites W2046507797 @default.
• W2055215877 cites W2051646461 @default.
• W2055215877 cites W2079010302 @default.
• W2055215877 cites W2081484463 @default.
• W2055215877 cites W2085822586 @default.
• W2055215877 cites W2096293149 @default.
• W2055215877 cites W2113271910 @default.
• W2055215877 cites W2118746879 @default.
• W2055215877 cites W2124131887 @default.
• W2055215877 cites W2133112835 @default.
• W2055215877 cites W2151007161 @default.
• W2055215877 cites W2154262200 @default.
• W2055215877 cites W2316318103 @default.
• W2055215877 doi "https://doi.org/10.1016/j.ijpharm.2009.05.061" @default.
• W2055215877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19505542" @default.
• W2055215877 hasPublicationYear "2009" @default.
• W2055215877 type Work @default.
• W2055215877 sameAs 2055215877 @default.
• W2055215877 citedByCount "22" @default.
• W2055215877 countsByYear W20552158772012 @default.
• W2055215877 countsByYear W20552158772013 @default.
• W2055215877 countsByYear W20552158772014 @default.
• W2055215877 countsByYear W20552158772015 @default.
• W2055215877 countsByYear W20552158772016 @default.
• W2055215877 countsByYear W20552158772020 @default.
• W2055215877 crossrefType "journal-article" @default.
• W2055215877 hasAuthorship W2055215877A5003885398 @default.
• W2055215877 hasAuthorship W2055215877A5015064590 @default.
• W2055215877 hasAuthorship W2055215877A5028415813 @default.
• W2055215877 hasAuthorship W2055215877A5078174247 @default.
• W2055215877 hasConcept C121332964 @default.
• W2055215877 hasConcept C131779359 @default.
• W2055215877 hasConcept C144082473 @default.
• W2055215877 hasConcept C147789679 @default.
• W2055215877 hasConcept C156911925 @default.
• W2055215877 hasConcept C161790260 @default.
• W2055215877 hasConcept C168191866 @default.
• W2055215877 hasConcept C178790620 @default.
• W2055215877 hasConcept C184651966 @default.
• W2055215877 hasConcept C184866935 @default.
• W2055215877 hasConcept C185592680 @default.
• W2055215877 hasConcept C188027245 @default.
• W2055215877 hasConcept C197404232 @default.
• W2055215877 hasConcept C3288061 @default.
• W2055215877 hasConcept C32909587 @default.
• W2055215877 hasConcept C45902088 @default.
• W2055215877 hasConcept C49152291 @default.
• W2055215877 hasConcept C557651011 @default.
• W2055215877 hasConcept C71240020 @default.
• W2055215877 hasConcept C8010536 @default.
• W2055215877 hasConcept C93275456 @default.
• W2055215877 hasConcept C97355855 @default.
• W2055215877 hasConceptScore W2055215877C121332964 @default.
• W2055215877 hasConceptScore W2055215877C131779359 @default.
• W2055215877 hasConceptScore W2055215877C144082473 @default.
• W2055215877 hasConceptScore W2055215877C147789679 @default.
• W2055215877 hasConceptScore W2055215877C156911925 @default.
• W2055215877 hasConceptScore W2055215877C161790260 @default.
• W2055215877 hasConceptScore W2055215877C168191866 @default.
• W2055215877 hasConceptScore W2055215877C178790620 @default.
• W2055215877 hasConceptScore W2055215877C184651966 @default.
• W2055215877 hasConceptScore W2055215877C184866935 @default.
• W2055215877 hasConceptScore W2055215877C185592680 @default.
• W2055215877 hasConceptScore W2055215877C188027245 @default.
• W2055215877 hasConceptScore W2055215877C197404232 @default.
• W2055215877 hasConceptScore W2055215877C3288061 @default.
• W2055215877 hasConceptScore W2055215877C32909587 @default.
• W2055215877 hasConceptScore W2055215877C45902088 @default.

• next