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• W2055216959 abstract "Abstract Neonicotinoids, such as imidacloprid, are key insecticides extensively used for control of Nilaparvata lugens . However, imidacloprid resistance has been reported in many Asian countries in recent years. To understand the roles of the chlorine atom of pyridyl group on insecticidal activity and resistance, the atom was removed to generate an imidacloprid analogue DC‐Imi (DesChlorine Imidacloprid). DC‐Imi showed significantly higher toxicity than imidacloprid in the susceptible strain of N. lugens , but had medium level cross‐resistance in an imidacloprid‐resistant strain. In Xenopus oocyte expressed nicotinic acetylcholine receptors (nAChRs) Nlα1/rβ2, the inward currents evoked by DC‐Imi were detected and could be blocked by typical nAChRs antagonist dihydro‐β‐erythroidine (DHβE), which demonstrated that DC‐Imi acted as an agonist on insect nAChRs. The efficacy of DC‐Imi on Nlα1/rβ2 was 1.8‐fold higher than that of imidacloprid. In addition, the influence of an imidacloprid resistance associated mutation (Y151S) on agonist potencies was evaluated. Compared with the wild‐type receptor, the mutation reduced maximal inward current of DC‐Imi to 55.6% and increased half maximal effective concentration ( EC 50 ) to 3.53‐fold. Compared with imidacloprid (increasing EC 50 to 2.38‐fold of wild‐type receptor), Y151S mutation decreased DC‐Imi potency more significantly. The results indicated that the selective and possibly high toxicities could be achieved through the modification of 6‐chloro‐3‐pyridyl group in imidacloprid and other neonicotinoids." @default.
• W2055216959 created "2016-06-24" @default.
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• W2055216959 date "2015-05-19" @default.
• W2055216959 modified "2023-10-03" @default.
• W2055216959 title "The insecticidal activity and action mode of an imidacloprid analogue, 1-(3-pyridylmethyl)-2-nitroimino-imidazolidine" @default.
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• W2055216959 doi "https://doi.org/10.1111/1744-7917.12217" @default.
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