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• W2055218633 abstract "Background: Despite screening of blood donors, hepatitis C virus (HCV) infection can occur in patients who receive multiple transfusions. Objective: To clarify mechanisms of nosocomial transmission of HCV. Design: Epidemiologic and molecular analyses of hepatitis C outbreaks. Setting: Pediatric oncology ward. Patients: Children with cancer. Measurements: Epidemiologic analysis, HCV RNA detection, genotyping, and hypervariable region 1 (HVR1) sequencing. Results: Ten cases of infection with acute HCV genotype 3a occurred between 1990 and 1993. Sequencing of HVR1 revealed three related strains. Despite an overhaul of hygiene procedures, a patient infected with genotype 1b generated nine subsequent infected patients in 1994. Several patients had high virus titers and strongly delayed anti-HCV antibody responses. All had permanent intravenous catheters. Multidose vials used for flushing or treatment had probably been contaminated during periods of overlapping treatment. Conclusions: Contamination of multidose vials was the most likely mode of HCV transmission; therefore, use of such vials should be restricted. Rigorous adherence to hygiene routines remains essential to preventing transmission of bloodborne infections." @default.
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• W2055218633 date "1999-01-19" @default.
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• W2055218633 title "Epidemiologic and Molecular Investigation of Outbreaks of Hepatitis C Virus Infection on a Pediatric Oncology Service" @default.
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• W2055218633 doi "https://doi.org/10.7326/0003-4819-130-2-199901190-00007" @default.
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