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• W2055223171 endingPage "171" @default.
• W2055223171 startingPage "159" @default.
• W2055223171 abstract "In the rat forced swimming test (FST), reuptake inhibitors selective of either serotonin (5-HT) or noradrenaline (NA) decrease immobility duration, and increase, respectively, swimming and climbing behaviour. In this study, an almost total 6-OHDA-induced NA-depletion prevented the behavioural effects of desipramine, but not fluoxetine. Interestingly, the serotonin/noradrenaline-reuptake-inhibitor milnacipran, as well as a (desipramine+fluoxetine) combination, could produce both swimming and climbing behaviour in NA-lesioned rats, but not in non-lesioned. The new antidepressant mirtazapine, which enhances both 5-HT and NA transmissions, supposedly through the antagonizing of α2-adrenoreceptors, dose-dependently reduced immobility and increased climbing behaviour. Interestingly, a (mirtazapine+fluoxetine) combination treatment resulted in additive anti-immobility effects and in the summation of fluoxetine-induced swimming with mirtazapine-induced climbing. Taken together, these data suggest that the NA system mediates presynaptic inhibiting interactions on the 5-HT system, that may involve α2-receptors, and that may limit the efficacy of mixed serotonin/noradrenaline reuptake inhibition in subacute antidepressant treatments." @default.
• W2055223171 created "2016-06-24" @default.
• W2055223171 creator A5015952224 @default.
• W2055223171 creator A5034486175 @default.
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• W2055223171 date "2002-04-01" @default.
• W2055223171 modified "2023-09-23" @default.
• W2055223171 title "In the rat forced swimming test, NA-system mediated interactions may prevent the 5-HT properties of some subacute antidepressant treatments being expressed" @default.
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• W2055223171 doi "https://doi.org/10.1016/s0924-977x(02)00007-x" @default.
• W2055223171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11872334" @default.
• W2055223171 hasPublicationYear "2002" @default.
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