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- W2055223867 abstract "Coupling of an inert polymer to the surface of red cells was examined as a potential means of covering blood group antigens and producing cells that could serve as universal donor cells for transfusion. Effective blockade of red cell antigens was achieved with N-hydroxysuccinimide-activated esters of polyethylene glycol. It was possible to block all antigens tested, but lower concentrations of reactants were required to block peptide-defined antigens than carbohydrate-defined antigens. Red cells remained intact after modification but were significantly damaged. Our results demonstrate the feasibility of antigenic blockade of red cells, but there is a need to reduce damage during coupling reactions to produce viable red cells." @default.
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- W2055223867 date "1997-01-01" @default.
- W2055223867 modified "2023-09-27" @default.
- W2055223867 title "Progress Toward Preparation of Universal Donor Red Cells" @default.
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- W2055223867 doi "https://doi.org/10.3109/10731199709118939" @default.
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