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- W2055230228 abstract "Oligodeoxynucleotides spanning codon 12 of the human c-Ha-ras gene were found to be exceptionally good substrates for de novo methylation by human DNA(cytosine-5)methyltransferase. In the complex formed by two complementary 30mers, only the C-rich strand was methylated by the enzyme. Guanines at the 3′ end of the G-rich strand of the complex could not be completely modified by dimethylsulfoxide suggesting tetrameric bonding at these G-residues. An eight-stranded structure, composed of four duplex DNAs at one end, joined to a G4-DNA segment at the other with the junction between the two DNA forms at codon 12, can account for our results." @default.
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- W2055230228 date "1989-05-01" @default.
- W2055230228 modified "2023-10-16" @default.
- W2055230228 title "A G4-DNA/B-DNA junction at codon 12 of c-Ha-ras is actively and asymmetrically methylated by DNA (cytosine-5)methyltransferase" @default.
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- W2055230228 doi "https://doi.org/10.1016/s0006-291x(89)80159-7" @default.
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