FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055235514> ?p ?o ?g. }

• W2055235514 endingPage "e82303" @default.
• W2055235514 startingPage "e82303" @default.
• W2055235514 abstract "Hepatic encephalopathy (HE) is an important cause of morbidity and mortality in patients with liver disease. The pathogenesis of he is incompletely understood although ammonia and inflammatory cytokines have been implicated as key mediators. To facilitate further mechanistic understanding of the pathogenesis of HE, a large number of animal models have been developed which often involve the surgical creation of an anastomosis between the hepatic portal vein and the caudal vena cava. One of the most common congenital abnormalities in dogs is a congenital portosystemic shunt (cpss), which closely mimics these surgical experimental models of HE. Dogs with a cPSS often have clinical signs which mimic clinical signs observed in humans with HE. Our hypothesis is that the pathogenesis of HE in dogs with a cPSS is similar to humans with HE. The aim of the study was to measure a range of clinical, haematological and biochemical parameters, which have been linked to the development of HE in humans, in dogs with a cPSS and a known HE grade. One hundred and twenty dogs with a cPSS were included in the study and multiple regression analysis of clinical, haematological and biochemical variables revealed that plasma ammonia concentrations and systemic inflammatory response syndrome scores predicted the presence of HE. Our findings further support the notion that the pathogenesis of canine and human HE share many similarities and indicate that dogs with cPSS may be an informative spontaneous model of human HE. Further investigations on dogs with cPSS may allow studies on HE to be undertaken without creating surgical models of HE thereby allowing the number of large animals used in animal experimentation to be reduced." @default.
• W2055235514 created "2016-06-24" @default.
• W2055235514 creator A5019917903 @default.
• W2055235514 creator A5036496686 @default.
• W2055235514 creator A5047324691 @default.
• W2055235514 creator A5053596593 @default.
• W2055235514 creator A5073789636 @default.
• W2055235514 creator A5075007848 @default.
• W2055235514 date "2014-01-02" @default.
• W2055235514 modified "2023-10-06" @default.
• W2055235514 title "Hyperammonemia and Systemic Inflammatory Response Syndrome Predicts Presence of Hepatic Encephalopathy in Dogs with Congenital Portosystemic Shunts" @default.
• W2055235514 cites W1036085 @default.
• W2055235514 cites W1495276461 @default.
• W2055235514 cites W154045452 @default.
• W2055235514 cites W1553819882 @default.
• W2055235514 cites W1665985473 @default.
• W2055235514 cites W1966279100 @default.
• W2055235514 cites W1972367583 @default.
• W2055235514 cites W1976667775 @default.
• W2055235514 cites W1979380304 @default.
• W2055235514 cites W1982049192 @default.
• W2055235514 cites W1990663367 @default.
• W2055235514 cites W1992634855 @default.
• W2055235514 cites W1993089591 @default.
• W2055235514 cites W1995620534 @default.
• W2055235514 cites W1996922627 @default.
• W2055235514 cites W2003049235 @default.
• W2055235514 cites W2006761821 @default.
• W2055235514 cites W2011375471 @default.
• W2055235514 cites W2015669226 @default.
• W2055235514 cites W2039183451 @default.
• W2055235514 cites W2039615827 @default.
• W2055235514 cites W2039816076 @default.
• W2055235514 cites W2054791647 @default.
• W2055235514 cites W2055162608 @default.
• W2055235514 cites W2059044221 @default.
• W2055235514 cites W2062759231 @default.
• W2055235514 cites W2063177432 @default.
• W2055235514 cites W2070726056 @default.
• W2055235514 cites W2072130498 @default.
• W2055235514 cites W2073170348 @default.
• W2055235514 cites W2074040512 @default.
• W2055235514 cites W2077449299 @default.
• W2055235514 cites W2077769893 @default.
• W2055235514 cites W2080582217 @default.
• W2055235514 cites W2088910001 @default.
• W2055235514 cites W2089865834 @default.
• W2055235514 cites W2092972998 @default.
• W2055235514 cites W2094074249 @default.
• W2055235514 cites W2097530146 @default.
• W2055235514 cites W2104585303 @default.
• W2055235514 cites W2112610029 @default.
• W2055235514 cites W2121095968 @default.
• W2055235514 cites W2121394480 @default.
• W2055235514 cites W2135074863 @default.
• W2055235514 cites W2151094561 @default.
• W2055235514 cites W2167965308 @default.
• W2055235514 cites W2395172939 @default.
• W2055235514 cites W4247723364 @default.
• W2055235514 cites W4323874767 @default.
• W2055235514 doi "https://doi.org/10.1371/journal.pone.0082303" @default.
• W2055235514 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3879253" @default.
• W2055235514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24392080" @default.
• W2055235514 hasPublicationYear "2014" @default.
• W2055235514 type Work @default.
• W2055235514 sameAs 2055235514 @default.
• W2055235514 citedByCount "42" @default.
• W2055235514 countsByYear W20552355142015 @default.
• W2055235514 countsByYear W20552355142016 @default.
• W2055235514 countsByYear W20552355142017 @default.
• W2055235514 countsByYear W20552355142018 @default.
• W2055235514 countsByYear W20552355142019 @default.
• W2055235514 countsByYear W20552355142020 @default.
• W2055235514 countsByYear W20552355142021 @default.
• W2055235514 countsByYear W20552355142022 @default.
• W2055235514 countsByYear W20552355142023 @default.
• W2055235514 crossrefType "journal-article" @default.
• W2055235514 hasAuthorship W2055235514A5019917903 @default.
• W2055235514 hasAuthorship W2055235514A5036496686 @default.
• W2055235514 hasAuthorship W2055235514A5047324691 @default.
• W2055235514 hasAuthorship W2055235514A5053596593 @default.
• W2055235514 hasAuthorship W2055235514A5073789636 @default.
• W2055235514 hasAuthorship W2055235514A5075007848 @default.
• W2055235514 hasBestOaLocation W20552355141 @default.
• W2055235514 hasConcept C126322002 @default.
• W2055235514 hasConcept C142724271 @default.
• W2055235514 hasConcept C2777214474 @default.
• W2055235514 hasConcept C2778384902 @default.
• W2055235514 hasConcept C2778621155 @default.
• W2055235514 hasConcept C2778674827 @default.
• W2055235514 hasConcept C2778808290 @default.
• W2055235514 hasConcept C2780325230 @default.
• W2055235514 hasConcept C2780942790 @default.
• W2055235514 hasConcept C2781090800 @default.
• W2055235514 hasConcept C2781099255 @default.
• W2055235514 hasConcept C63363279 @default.
• W2055235514 hasConcept C71924100 @default.
• W2055235514 hasConcept C90924648 @default.

• next