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- W2055242795 abstract "In this work we selected double-stranded DNA sequences capable of forming stable triplexes at 20 or 50°C with corresponding 13mer purine oligo-nucleotides. This selection was obtained by a double aptamer approach where both the starting sequences of the oligonucleotides and the target DNA duplex were random. The results of selection were confirmed by a cold exchange method and the influence of the position of a ‘mismatch’ on the stability of the triplex was documented in several cases. The selected sequences obey two rules: (i) they have a high G content; (ii) for a given G content the stability of the resulting triplex is higher if the G residues lie in stretches. The computer simulation of the Mg 2+ , Na + and Cl - environment around three triplexes by a density scaled Monte Carlo method provides an interpretation of the experimental observations. The Mg 2+ cations are statistically close to the G N7 and relatively far from the A N7. The presence of an A repels the Mg 2+ from adjacent G residues. Therefore, the triplexes are stabilized when the Mg 2+ can form a continuous spine on G N7." @default.
- W2055242795 created "2016-06-24" @default.
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- W2055242795 date "1999-07-01" @default.
- W2055242795 modified "2023-10-16" @default.
- W2055242795 title "Stability of G,A triple helices" @default.
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- W2055242795 doi "https://doi.org/10.1093/nar/27.13.2699" @default.
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