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• W2055258885 startingPage "1035" @default.
• W2055258885 abstract "The development of oligodendrocytes from their precursor cells through different developmental stages can be studied in vitro. These stages can be distinguished by specific monoclonal antibodies and by a characteristic K+ channel profile. In this study we demonstrate that the occurrence of Ca2+ currents also undergoes marked changes during the development of mouse oligodendrocytes. Immature precursor cells which can develop into astrocytes or oligodendrocytes expressed two different types of voltage-activated Ca2+ channels. The expression of Ca2+ channels in precursor cells was strongly correlated with the expression of Na+ channels. When cells started to express the O1 antigen and were committed to the oligodendrocyte lineage, Ca2+ and Na+ currents could no longer be detected. Large Ca2+ currents were, however, recorded later in the development of the oligodendrocytes, correlated with the expression of the O10 antigen. The Ca2+ channels were classified as high and low voltage-activated Ca2+ channels according to their range of activation, and are further described by their kinetic and pharmacological properties." @default.
• W2055258885 created "2016-06-24" @default.
• W2055258885 creator A5025107630 @default.
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• W2055258885 date "1992-11-01" @default.
• W2055258885 modified "2023-09-26" @default.
• W2055258885 title "Ca²⁺Channel Expression in the Oligodendrocyte Lineage" @default.
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• W2055258885 doi "https://doi.org/10.1111/j.1460-9568.1992.tb00130.x" @default.
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