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- W2055264554 abstract "The step-economical synthesis of a new class of bryostatin analogues that contain the complete oxycarbocyclic core ring system of the bryostatin natural products is reported. These agents are convergently assembled via a highly efficient, functional-group-tolerant, and stereoselective Prins-driven macrocyclization. These tetrahydropyranyl B-ring analogues are among our most potent and efficacious analogues to date, exhibiting nanomolar and picomolar activities in protein kinase C affinity assays as well as in cellular antiproliferation assays." @default.
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- W2055264554 date "2008-05-01" @default.
- W2055264554 modified "2023-09-26" @default.
- W2055264554 title "Efficient Synthetic Access to a New Family of Highly Potent Bryostatin Analogues via a Prins-Driven Macrocyclization Strategy" @default.
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- W2055264554 doi "https://doi.org/10.1021/ja8015632" @default.
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