FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055264776> ?p ?o ?g. }

• W2055264776 endingPage "554" @default.
• W2055264776 startingPage "545" @default.
• W2055264776 abstract "The aim of the present work was to determine whether the accumulation of Ig mRNA in myeloma cells is due to a high rate of production or to a high stability of these molecules. Specific mRNAs for the light and heavy polypeptide chains of IgG were isolated from the murine MPC-11 myeloma tumor cells by immune precipitation of polysomes which synthesize these chains. It was found that the immune-precipitated polysomes were enriched 10 –30-fold in the γ and χ mRNA sequences respectively. In the wheal germ cell-free system the χ mRNA preparation was translated mainly into three polypeptides of Mr 25000, 18000, and 15000. The method of immune precipitation of polysomes was also used to characterize three variant clones of MPC-11 myeloma. It was found that little if any γ-chain polysomes are present in the L-chain producer and non-producer clones, while a substantial amount of χ-chain polysomes was present in the non-producer clone. This may be due to the presence in the non-producer cells of the constant region χ-chain fragment. In order to determine the relative synthesis rate of χ and γ mRNAs, pulse-labeled polysomes were immune precipitated using antibodies to χ and γ chains. It was found that χ and γ mRNA molecules are produced at a very high relative rate each accounting for 10–15% of the total labeled mRNA after 1 h of labeling. These values are higher than the steady-state pool size of χ and γ mRNA, which was 5–6%, and indicates that the half-life of these molecules is not unusually high. It is concluded that the amplified synthesis of immunoglobulin chains in myeloma cells is mainly due to a high rate of production of translatable χ and γ mRNAs." @default.
• W2055264776 created "2016-06-24" @default.
• W2055264776 creator A5023612823 @default.
• W2055264776 creator A5037100688 @default.
• W2055264776 date "1980-09-01" @default.
• W2055264776 modified "2023-10-14" @default.
• W2055264776 title "A High Production Rate of Translatable IgG mRNA Accounts for the Amplified Synthesis of IgG in Myeloma Cells" @default.
• W2055264776 cites W1533986497 @default.
• W2055264776 cites W1534004384 @default.
• W2055264776 cites W1544621414 @default.
• W2055264776 cites W1547211724 @default.
• W2055264776 cites W1969701389 @default.
• W2055264776 cites W1974096637 @default.
• W2055264776 cites W2000971934 @default.
• W2055264776 cites W2001494787 @default.
• W2055264776 cites W2007307125 @default.
• W2055264776 cites W2008479196 @default.
• W2055264776 cites W2009792321 @default.
• W2055264776 cites W2010984701 @default.
• W2055264776 cites W2013651327 @default.
• W2055264776 cites W2015880687 @default.
• W2055264776 cites W2018378086 @default.
• W2055264776 cites W2031108602 @default.
• W2055264776 cites W2035733505 @default.
• W2055264776 cites W2038123178 @default.
• W2055264776 cites W2038630003 @default.
• W2055264776 cites W2066160869 @default.
• W2055264776 cites W2068347563 @default.
• W2055264776 cites W2071868080 @default.
• W2055264776 cites W2078281648 @default.
• W2055264776 cites W2082221845 @default.
• W2055264776 cites W2083150027 @default.
• W2055264776 cites W2090321719 @default.
• W2055264776 cites W2112511894 @default.
• W2055264776 cites W2123424881 @default.
• W2055264776 cites W2137911181 @default.
• W2055264776 cites W2152267392 @default.
• W2055264776 cites W2285045057 @default.
• W2055264776 cites W4244157880 @default.
• W2055264776 doi "https://doi.org/10.1111/j.1432-1033.1980.tb04897.x" @default.
• W2055264776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7439173" @default.
• W2055264776 hasPublicationYear "1980" @default.
• W2055264776 type Work @default.
• W2055264776 sameAs 2055264776 @default.
• W2055264776 citedByCount "5" @default.
• W2055264776 countsByYear W20552647762012 @default.
• W2055264776 crossrefType "journal-article" @default.
• W2055264776 hasAuthorship W2055264776A5023612823 @default.
• W2055264776 hasAuthorship W2055264776A5037100688 @default.
• W2055264776 hasBestOaLocation W20552647761 @default.
• W2055264776 hasConcept C104317684 @default.
• W2055264776 hasConcept C105580179 @default.
• W2055264776 hasConcept C153911025 @default.
• W2055264776 hasConcept C159654299 @default.
• W2055264776 hasConcept C185592680 @default.
• W2055264776 hasConcept C203014093 @default.
• W2055264776 hasConcept C36394416 @default.
• W2055264776 hasConcept C3675279 @default.
• W2055264776 hasConcept C55493867 @default.
• W2055264776 hasConcept C65666806 @default.
• W2055264776 hasConcept C67705224 @default.
• W2055264776 hasConcept C81089528 @default.
• W2055264776 hasConcept C86803240 @default.
• W2055264776 hasConcept C88478588 @default.
• W2055264776 hasConcept C8891405 @default.
• W2055264776 hasConceptScore W2055264776C104317684 @default.
• W2055264776 hasConceptScore W2055264776C105580179 @default.
• W2055264776 hasConceptScore W2055264776C153911025 @default.
• W2055264776 hasConceptScore W2055264776C159654299 @default.
• W2055264776 hasConceptScore W2055264776C185592680 @default.
• W2055264776 hasConceptScore W2055264776C203014093 @default.
• W2055264776 hasConceptScore W2055264776C36394416 @default.
• W2055264776 hasConceptScore W2055264776C3675279 @default.
• W2055264776 hasConceptScore W2055264776C55493867 @default.
• W2055264776 hasConceptScore W2055264776C65666806 @default.
• W2055264776 hasConceptScore W2055264776C67705224 @default.
• W2055264776 hasConceptScore W2055264776C81089528 @default.
• W2055264776 hasConceptScore W2055264776C86803240 @default.
• W2055264776 hasConceptScore W2055264776C88478588 @default.
• W2055264776 hasConceptScore W2055264776C8891405 @default.
• W2055264776 hasIssue "2" @default.
• W2055264776 hasLocation W20552647761 @default.
• W2055264776 hasLocation W20552647762 @default.
• W2055264776 hasOpenAccess W2055264776 @default.
• W2055264776 hasPrimaryLocation W20552647761 @default.
• W2055264776 hasRelatedWork W1071128 @default.
• W2055264776 hasRelatedWork W1542947162 @default.
• W2055264776 hasRelatedWork W2012612245 @default.
• W2055264776 hasRelatedWork W2033070239 @default.
• W2055264776 hasRelatedWork W2066540780 @default.
• W2055264776 hasRelatedWork W2106651791 @default.
• W2055264776 hasRelatedWork W2344162975 @default.
• W2055264776 hasRelatedWork W2410252831 @default.
• W2055264776 hasRelatedWork W2418504831 @default.
• W2055264776 hasRelatedWork W2994002666 @default.
• W2055264776 hasVolume "110" @default.
• W2055264776 isParatext "false" @default.
• W2055264776 isRetracted "false" @default.

• next