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- W2055269711 abstract "The hydrophobic lung surfactant SP-B is essential for respiration. SP-B promotes spreading and adsorption of surfactant at the alveolar air-water interface and may facilitate connections between the surface layer and underlying lamellar reservoirs of surfactant material. SP-B63–78 is a cationic and amphipathic helical peptide containing the C-terminal helix of SP-B. 2H NMR has been used to examine the effect of SP-B63–78 on the phase behavior and dynamics of bicellar lipid dispersions containing the longer chain phospholipids DMPC-d54 and DMPG and the shorter chain lipid DHPC mixed with a 3∶1∶1 molar ratio. Below the gel-to-liquid crystal phase transition temperature of the longer chain components, bicellar mixtures form small, rapidly reorienting disk-like particles with shorter chain lipid components predominantly found around the highly curved particle edges. With increasing temperature, the particles coalesce into larger magnetically-oriented structures and then into more extended lamellar phases. The susceptibility of bicellar particles to coalescence and large scale reorganization makes them an interesting platform in which to study peptide-induced interactions between lipid assemblies. SP-B63–78 is found to lower the temperature at which the orientable phase transforms to the more extended lamellar phase. The peptide also changes the spectrum of motions contributing to quadrupole echo decay in the lamellar phase. The way in which the peptide alters interactions between bilayered micelle structures may provide some insight into some aspects of the role of full-length SP-B in maintaining a functional surfactant layer in lungs." @default.
- W2055269711 created "2016-06-24" @default.
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- W2055269711 creator A5013940285 @default.
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- W2055269711 creator A5083047067 @default.
- W2055269711 date "2013-08-26" @default.
- W2055269711 modified "2023-09-24" @default.
- W2055269711 title "Interaction of the C-Terminal Peptide of Pulmonary Surfactant Protein B (SP-B) with a Bicellar Lipid Mixture Containing Anionic Lipid" @default.
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- W2055269711 doi "https://doi.org/10.1371/journal.pone.0072248" @default.
- W2055269711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3753361" @default.
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- W2055269711 hasPublicationYear "2013" @default.
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