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• W2055274600 abstract "The nonsteroidal antiestrogen tamoxifen increases the risk of endometrial cancer; however, the mechanism for the induction of these tumors is not known. Recently, Sharma et al. [Biochem. Biophys. Res. Commun. 307 (2003) 157], using high performance liquid chromatography (HPLC) with online postcolumn photochemical activation and fluorescence detection, reported the presence of (E)-alpha-(deoxyguanosin- N2-yl)tamoxifen in DNA from human endometrial explants incubated with tamoxifen. Inasmuch as the methodology used by these investigators does not allow unambiguous characterization of tamoxifen-DNA adducts, we have used two additional techniques (HPLC coupled with electrospray ionization tandem mass spectrometry and 32P-postlabeling analyses) to assay for the presence of tamoxifen-DNA adducts in the human endometrial explant DNA. Tamoxifen-DNA adducts were not detected by either method." @default.
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• W2055274600 date "2004-07-01" @default.
• W2055274600 modified "2023-09-27" @default.
• W2055274600 title "Analysis of tamoxifen–DNA adducts in endometrial explants by MS and 32P-postlabeling" @default.
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• W2055274600 doi "https://doi.org/10.1016/j.bbrc.2004.05.168" @default.
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